Found 2 hits Enz. Inhib. hit(s) with Target = 'Diacylglycerol O-acyltransferase 1' and Ligand = 'BDBM50020054' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Diacylglycerol O-acyltransferase 1
(Mus musculus (mouse)) | BDBM50020054
(CHEMBL3287890)Show SMILES OC(=O)C[C@H]1CC[C@H](CC1)c1ccc(cc1)-c1ccc2N(CCOc2c1)C(=O)Nc1ccccc1 |r,wU:7.10,4.3,(19.8,-5.61,;18.48,-6.41,;17.13,-5.67,;18.52,-7.95,;17.21,-8.75,;17.24,-10.29,;15.93,-11.08,;14.58,-10.34,;14.54,-8.8,;15.86,-8.01,;13.26,-11.14,;11.91,-10.4,;10.6,-11.2,;10.64,-12.74,;11.99,-13.48,;13.3,-12.68,;9.32,-13.54,;9.36,-15.08,;8.05,-15.88,;6.7,-15.14,;5.38,-15.94,;4.03,-15.2,;3.99,-13.66,;5.31,-12.86,;6.66,-13.6,;7.97,-12.8,;5.42,-17.48,;6.76,-18.21,;4.1,-18.28,;4.14,-19.82,;2.82,-20.61,;2.86,-22.15,;4.21,-22.89,;5.53,-22.08,;5.49,-20.55,)| Show InChI InChI=1S/C29H30N2O4/c32-28(33)18-20-6-8-21(9-7-20)22-10-12-23(13-11-22)24-14-15-26-27(19-24)35-17-16-31(26)29(34)30-25-4-2-1-3-5-25/h1-5,10-15,19-21H,6-9,16-18H2,(H,30,34)(H,32,33)/t20-,21+ | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 45 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of mouse DGAT1 expressed in Sf9 insect cells using 1,2-dioleoyl-sn-glycerol and [14C]-palmitoyl-CoA substrate by scintillation counting an... |
ACS Med Chem Lett 5: 544-9 (2014)
Article DOI: 10.1021/ml400527n
BindingDB Entry DOI: 10.7270/Q2KS6T3C |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM50020054
(CHEMBL3287890)Show SMILES OC(=O)C[C@H]1CC[C@H](CC1)c1ccc(cc1)-c1ccc2N(CCOc2c1)C(=O)Nc1ccccc1 |r,wU:7.10,4.3,(19.8,-5.61,;18.48,-6.41,;17.13,-5.67,;18.52,-7.95,;17.21,-8.75,;17.24,-10.29,;15.93,-11.08,;14.58,-10.34,;14.54,-8.8,;15.86,-8.01,;13.26,-11.14,;11.91,-10.4,;10.6,-11.2,;10.64,-12.74,;11.99,-13.48,;13.3,-12.68,;9.32,-13.54,;9.36,-15.08,;8.05,-15.88,;6.7,-15.14,;5.38,-15.94,;4.03,-15.2,;3.99,-13.66,;5.31,-12.86,;6.66,-13.6,;7.97,-12.8,;5.42,-17.48,;6.76,-18.21,;4.1,-18.28,;4.14,-19.82,;2.82,-20.61,;2.86,-22.15,;4.21,-22.89,;5.53,-22.08,;5.49,-20.55,)| Show InChI InChI=1S/C29H30N2O4/c32-28(33)18-20-6-8-21(9-7-20)22-10-12-23(13-11-22)24-14-15-26-27(19-24)35-17-16-31(26)29(34)30-25-4-2-1-3-5-25/h1-5,10-15,19-21H,6-9,16-18H2,(H,30,34)(H,32,33)/t20-,21+ | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 52 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human DGAT1 expressed in Sf9 insect cells using 1,2-dioleoyl-sn-glycerol and [14C]-palmitoyl-CoA substrate by scintillation counting an... |
ACS Med Chem Lett 5: 544-9 (2014)
Article DOI: 10.1021/ml400527n
BindingDB Entry DOI: 10.7270/Q2KS6T3C |
More data for this
Ligand-Target Pair | |
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