Found 2 hits Enz. Inhib. hit(s) with Target = 'Diacylglycerol O-acyltransferase 1' and Ligand = 'BDBM50020058' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Diacylglycerol O-acyltransferase 1
(Mus musculus (mouse)) | BDBM50020058
(CHEMBL3287883)Show SMILES OC(=O)C[C@H]1CC[C@@H](CC1)c1ccc(cc1)-c1ccc2N(CCOc2c1)C(=O)NC1CCCCC1 |r,wU:7.10,wD:4.3,(22.51,3.03,;21.2,2.23,;19.84,2.96,;21.23,.69,;19.92,-.12,;18.57,.63,;17.25,-.18,;17.29,-1.72,;18.64,-2.46,;19.95,-1.66,;15.97,-2.52,;14.62,-1.78,;13.31,-2.58,;13.35,-4.12,;14.7,-4.86,;16.01,-4.06,;12.03,-4.92,;12.07,-6.46,;10.75,-7.26,;9.4,-6.52,;8.09,-7.32,;6.74,-6.58,;6.7,-5.04,;8.01,-4.24,;9.37,-4.98,;10.68,-4.18,;8.12,-8.86,;9.47,-9.6,;6.81,-9.66,;6.84,-11.2,;5.54,-11.99,;5.56,-13.52,;6.91,-14.26,;8.22,-13.47,;8.19,-11.93,)| Show InChI InChI=1S/C29H36N2O4/c32-28(33)18-20-6-8-21(9-7-20)22-10-12-23(13-11-22)24-14-15-26-27(19-24)35-17-16-31(26)29(34)30-25-4-2-1-3-5-25/h10-15,19-21,25H,1-9,16-18H2,(H,30,34)(H,32,33)/t20-,21- | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 160 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of mouse DGAT1 expressed in Sf9 insect cells using 1,2-dioleoyl-sn-glycerol and [14C]-palmitoyl-CoA substrate by scintillation counting an... |
ACS Med Chem Lett 5: 544-9 (2014)
Article DOI: 10.1021/ml400527n
BindingDB Entry DOI: 10.7270/Q2KS6T3C |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM50020058
(CHEMBL3287883)Show SMILES OC(=O)C[C@H]1CC[C@@H](CC1)c1ccc(cc1)-c1ccc2N(CCOc2c1)C(=O)NC1CCCCC1 |r,wU:7.10,wD:4.3,(22.51,3.03,;21.2,2.23,;19.84,2.96,;21.23,.69,;19.92,-.12,;18.57,.63,;17.25,-.18,;17.29,-1.72,;18.64,-2.46,;19.95,-1.66,;15.97,-2.52,;14.62,-1.78,;13.31,-2.58,;13.35,-4.12,;14.7,-4.86,;16.01,-4.06,;12.03,-4.92,;12.07,-6.46,;10.75,-7.26,;9.4,-6.52,;8.09,-7.32,;6.74,-6.58,;6.7,-5.04,;8.01,-4.24,;9.37,-4.98,;10.68,-4.18,;8.12,-8.86,;9.47,-9.6,;6.81,-9.66,;6.84,-11.2,;5.54,-11.99,;5.56,-13.52,;6.91,-14.26,;8.22,-13.47,;8.19,-11.93,)| Show InChI InChI=1S/C29H36N2O4/c32-28(33)18-20-6-8-21(9-7-20)22-10-12-23(13-11-22)24-14-15-26-27(19-24)35-17-16-31(26)29(34)30-25-4-2-1-3-5-25/h10-15,19-21,25H,1-9,16-18H2,(H,30,34)(H,32,33)/t20-,21- | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 230 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human DGAT1 expressed in Sf9 insect cells using 1,2-dioleoyl-sn-glycerol and [14C]-palmitoyl-CoA substrate by scintillation counting an... |
ACS Med Chem Lett 5: 544-9 (2014)
Article DOI: 10.1021/ml400527n
BindingDB Entry DOI: 10.7270/Q2KS6T3C |
More data for this
Ligand-Target Pair | |
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