Found 2 hits Enz. Inhib. hit(s) with Target = 'Diacylglycerol O-acyltransferase 1' and Ligand = 'BDBM50020069' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Diacylglycerol O-acyltransferase 1
(Mus musculus (mouse)) | BDBM50020069
(CHEMBL3287869)Show SMILES OC(=O)C[C@H]1CC[C@@H](CC1)c1ccc(cc1)-c1ccc2N(CCOc2c1)C(=O)Cc1ccccc1 |r,wU:7.10,wD:4.3,(22.61,-2.81,;21.3,-3.62,;21.35,-5.16,;19.94,-2.9,;18.64,-3.71,;17.28,-2.99,;15.97,-3.81,;16.02,-5.34,;17.38,-6.07,;18.69,-5.25,;14.72,-6.16,;13.35,-5.43,;12.05,-6.24,;12.1,-7.78,;13.46,-8.51,;14.76,-7.7,;10.79,-8.6,;10.85,-10.14,;9.54,-10.95,;8.18,-10.23,;6.86,-11.05,;5.5,-10.31,;5.46,-8.76,;6.78,-7.95,;8.13,-8.69,;9.44,-7.87,;6.91,-12.58,;8.26,-13.31,;5.6,-13.39,;5.65,-14.92,;4.34,-15.71,;4.39,-17.25,;5.74,-17.98,;7.05,-17.16,;6.99,-15.63,)| Show InChI InChI=1S/C30H31NO4/c32-29(18-21-4-2-1-3-5-21)31-16-17-35-28-20-26(14-15-27(28)31)25-12-10-24(11-13-25)23-8-6-22(7-9-23)19-30(33)34/h1-5,10-15,20,22-23H,6-9,16-19H2,(H,33,34)/t22-,23- | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of mouse DGAT1 expressed in Sf9 insect cells using 1,2-dioleoyl-sn-glycerol and [14C]-palmitoyl-CoA substrate by scintillation counting an... |
ACS Med Chem Lett 5: 544-9 (2014)
Article DOI: 10.1021/ml400527n
BindingDB Entry DOI: 10.7270/Q2KS6T3C |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM50020069
(CHEMBL3287869)Show SMILES OC(=O)C[C@H]1CC[C@@H](CC1)c1ccc(cc1)-c1ccc2N(CCOc2c1)C(=O)Cc1ccccc1 |r,wU:7.10,wD:4.3,(22.61,-2.81,;21.3,-3.62,;21.35,-5.16,;19.94,-2.9,;18.64,-3.71,;17.28,-2.99,;15.97,-3.81,;16.02,-5.34,;17.38,-6.07,;18.69,-5.25,;14.72,-6.16,;13.35,-5.43,;12.05,-6.24,;12.1,-7.78,;13.46,-8.51,;14.76,-7.7,;10.79,-8.6,;10.85,-10.14,;9.54,-10.95,;8.18,-10.23,;6.86,-11.05,;5.5,-10.31,;5.46,-8.76,;6.78,-7.95,;8.13,-8.69,;9.44,-7.87,;6.91,-12.58,;8.26,-13.31,;5.6,-13.39,;5.65,-14.92,;4.34,-15.71,;4.39,-17.25,;5.74,-17.98,;7.05,-17.16,;6.99,-15.63,)| Show InChI InChI=1S/C30H31NO4/c32-29(18-21-4-2-1-3-5-21)31-16-17-35-28-20-26(14-15-27(28)31)25-12-10-24(11-13-25)23-8-6-22(7-9-23)19-30(33)34/h1-5,10-15,20,22-23H,6-9,16-19H2,(H,33,34)/t22-,23- | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 580 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human DGAT1 expressed in Sf9 insect cells using 1,2-dioleoyl-sn-glycerol and [14C]-palmitoyl-CoA substrate by scintillation counting an... |
ACS Med Chem Lett 5: 544-9 (2014)
Article DOI: 10.1021/ml400527n
BindingDB Entry DOI: 10.7270/Q2KS6T3C |
More data for this
Ligand-Target Pair | |
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