Found 2 hits Enz. Inhib. hit(s) with Target = 'Diacylglycerol O-acyltransferase 1' and Ligand = 'BDBM50020070' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Diacylglycerol O-acyltransferase 1
(Mus musculus (mouse)) | BDBM50020070
(CHEMBL3287881)Show SMILES OC(=O)C[C@H]1CC[C@@H](CC1)c1ccc(cc1)-c1ccc2N(CCOc2c1)C(=O)NCc1ccccc1 |r,wU:7.10,wD:4.3,(20.88,.99,;19.56,.19,;18.21,.93,;19.6,-1.36,;18.29,-2.16,;16.93,-1.42,;15.62,-2.22,;15.66,-3.76,;17.01,-4.5,;18.32,-3.7,;14.34,-4.56,;12.99,-3.82,;11.68,-4.62,;11.71,-6.16,;13.06,-6.9,;14.38,-6.1,;10.4,-6.96,;10.44,-8.5,;9.12,-9.3,;7.77,-8.56,;6.46,-9.36,;5.1,-8.62,;5.07,-7.08,;6.38,-6.28,;7.73,-7.02,;9.05,-6.22,;6.49,-10.9,;7.84,-11.63,;5.18,-11.7,;5.21,-13.23,;3.9,-14.03,;2.55,-13.29,;1.24,-14.09,;1.28,-15.63,;2.63,-16.36,;3.94,-15.56,)| Show InChI InChI=1S/C30H32N2O4/c33-29(34)18-21-6-8-23(9-7-21)24-10-12-25(13-11-24)26-14-15-27-28(19-26)36-17-16-32(27)30(35)31-20-22-4-2-1-3-5-22/h1-5,10-15,19,21,23H,6-9,16-18,20H2,(H,31,35)(H,33,34)/t21-,23- | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of mouse DGAT1 expressed in Sf9 insect cells using 1,2-dioleoyl-sn-glycerol and [14C]-palmitoyl-CoA substrate by scintillation counting an... |
ACS Med Chem Lett 5: 544-9 (2014)
Article DOI: 10.1021/ml400527n
BindingDB Entry DOI: 10.7270/Q2KS6T3C |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM50020070
(CHEMBL3287881)Show SMILES OC(=O)C[C@H]1CC[C@@H](CC1)c1ccc(cc1)-c1ccc2N(CCOc2c1)C(=O)NCc1ccccc1 |r,wU:7.10,wD:4.3,(20.88,.99,;19.56,.19,;18.21,.93,;19.6,-1.36,;18.29,-2.16,;16.93,-1.42,;15.62,-2.22,;15.66,-3.76,;17.01,-4.5,;18.32,-3.7,;14.34,-4.56,;12.99,-3.82,;11.68,-4.62,;11.71,-6.16,;13.06,-6.9,;14.38,-6.1,;10.4,-6.96,;10.44,-8.5,;9.12,-9.3,;7.77,-8.56,;6.46,-9.36,;5.1,-8.62,;5.07,-7.08,;6.38,-6.28,;7.73,-7.02,;9.05,-6.22,;6.49,-10.9,;7.84,-11.63,;5.18,-11.7,;5.21,-13.23,;3.9,-14.03,;2.55,-13.29,;1.24,-14.09,;1.28,-15.63,;2.63,-16.36,;3.94,-15.56,)| Show InChI InChI=1S/C30H32N2O4/c33-29(34)18-21-6-8-23(9-7-21)24-10-12-25(13-11-24)26-14-15-27-28(19-26)36-17-16-32(27)30(35)31-20-22-4-2-1-3-5-22/h1-5,10-15,19,21,23H,6-9,16-18,20H2,(H,31,35)(H,33,34)/t21-,23- | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 580 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human DGAT1 expressed in Sf9 insect cells using 1,2-dioleoyl-sn-glycerol and [14C]-palmitoyl-CoA substrate by scintillation counting an... |
ACS Med Chem Lett 5: 544-9 (2014)
Article DOI: 10.1021/ml400527n
BindingDB Entry DOI: 10.7270/Q2KS6T3C |
More data for this
Ligand-Target Pair | |
Search and Browse
