Found 2 hits Enz. Inhib. hit(s) with Target = 'Diacylglycerol O-acyltransferase 1' and Ligand = 'BDBM50020081' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Diacylglycerol O-acyltransferase 1
(Mus musculus (mouse)) | BDBM50020081
(CHEMBL3287863)Show SMILES CC1Oc2cc(ccc2N(C(=O)Nc2ccccc2)C1=O)-c1ccc(cc1)[C@H]1CC[C@H](CC(O)=O)CC1 |r,wU:27.30,wD:30.34,(3,-8.79,;3.77,-7.46,;5.31,-7.46,;6.08,-6.13,;7.62,-6.13,;8.39,-4.79,;7.62,-3.46,;6.08,-3.46,;5.31,-4.79,;3.77,-4.79,;3,-3.46,;3.77,-2.13,;1.46,-3.46,;.69,-2.13,;-.85,-2.13,;-1.62,-.79,;-.85,.54,;.69,.54,;1.46,-.79,;3,-6.13,;1.46,-6.13,;9.93,-4.79,;10.7,-6.13,;12.24,-6.13,;13.01,-4.79,;12.24,-3.46,;10.7,-3.46,;14.55,-4.79,;15.32,-3.46,;16.86,-3.46,;17.63,-4.79,;19.17,-4.79,;19.94,-6.13,;21.48,-6.13,;19.17,-7.46,;16.86,-6.13,;15.32,-6.13,)| Show InChI InChI=1S/C30H30N2O5/c1-19-29(35)32(30(36)31-25-5-3-2-4-6-25)26-16-15-24(18-27(26)37-19)23-13-11-22(12-14-23)21-9-7-20(8-10-21)17-28(33)34/h2-6,11-16,18-21H,7-10,17H2,1H3,(H,31,36)(H,33,34)/t19?,20-,21- | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of mouse DGAT1 expressed in Sf9 insect cells using 1,2-dioleoyl-sn-glycerol and [14C]-palmitoyl-CoA substrate by scintillation counting an... |
ACS Med Chem Lett 5: 544-9 (2014)
Article DOI: 10.1021/ml400527n
BindingDB Entry DOI: 10.7270/Q2KS6T3C |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM50020081
(CHEMBL3287863)Show SMILES CC1Oc2cc(ccc2N(C(=O)Nc2ccccc2)C1=O)-c1ccc(cc1)[C@H]1CC[C@H](CC(O)=O)CC1 |r,wU:27.30,wD:30.34,(3,-8.79,;3.77,-7.46,;5.31,-7.46,;6.08,-6.13,;7.62,-6.13,;8.39,-4.79,;7.62,-3.46,;6.08,-3.46,;5.31,-4.79,;3.77,-4.79,;3,-3.46,;3.77,-2.13,;1.46,-3.46,;.69,-2.13,;-.85,-2.13,;-1.62,-.79,;-.85,.54,;.69,.54,;1.46,-.79,;3,-6.13,;1.46,-6.13,;9.93,-4.79,;10.7,-6.13,;12.24,-6.13,;13.01,-4.79,;12.24,-3.46,;10.7,-3.46,;14.55,-4.79,;15.32,-3.46,;16.86,-3.46,;17.63,-4.79,;19.17,-4.79,;19.94,-6.13,;21.48,-6.13,;19.17,-7.46,;16.86,-6.13,;15.32,-6.13,)| Show InChI InChI=1S/C30H30N2O5/c1-19-29(35)32(30(36)31-25-5-3-2-4-6-25)26-16-15-24(18-27(26)37-19)23-13-11-22(12-14-23)21-9-7-20(8-10-21)17-28(33)34/h2-6,11-16,18-21H,7-10,17H2,1H3,(H,31,36)(H,33,34)/t19?,20-,21- | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human DGAT1 expressed in Sf9 insect cells using 1,2-dioleoyl-sn-glycerol and [14C]-palmitoyl-CoA substrate by scintillation counting an... |
ACS Med Chem Lett 5: 544-9 (2014)
Article DOI: 10.1021/ml400527n
BindingDB Entry DOI: 10.7270/Q2KS6T3C |
More data for this
Ligand-Target Pair | |
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