Found 2 hits Enz. Inhib. hit(s) with Target = 'Diacylglycerol O-acyltransferase 1' and Ligand = 'BDBM50020082' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Diacylglycerol O-acyltransferase 1
(Mus musculus (mouse)) | BDBM50020082
(CHEMBL3287871)Show SMILES OC(=O)C[C@H]1CC[C@@H](CC1)c1ccc(cc1)-c1ccc2N(CCOc2c1)S(=O)(=O)Cc1ccccc1 |r,wU:7.10,wD:4.3,(29.7,-15.27,;31.04,-16.03,;32.36,-15.24,;31.06,-17.57,;29.73,-18.35,;28.39,-17.59,;27.07,-18.38,;27.09,-19.92,;28.43,-20.67,;29.75,-19.89,;25.76,-20.7,;24.42,-19.94,;23.1,-20.73,;23.12,-22.27,;24.46,-23.02,;25.78,-22.24,;21.79,-23.05,;21.81,-24.59,;20.49,-25.37,;19.15,-24.62,;17.82,-25.4,;16.48,-24.64,;16.47,-23.1,;17.79,-22.32,;19.13,-23.07,;20.45,-22.29,;17.84,-26.93,;16.35,-26.52,;17.44,-28.4,;19.16,-27.72,;19.12,-29.26,;17.78,-30,;17.75,-31.54,;19.06,-32.34,;20.4,-31.6,;20.44,-30.06,)| Show InChI InChI=1S/C29H31NO5S/c31-29(32)18-21-6-8-23(9-7-21)24-10-12-25(13-11-24)26-14-15-27-28(19-26)35-17-16-30(27)36(33,34)20-22-4-2-1-3-5-22/h1-5,10-15,19,21,23H,6-9,16-18,20H2,(H,31,32)/t21-,23- | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of mouse DGAT1 expressed in Sf9 insect cells using 1,2-dioleoyl-sn-glycerol and [14C]-palmitoyl-CoA substrate by scintillation counting an... |
ACS Med Chem Lett 5: 544-9 (2014)
Article DOI: 10.1021/ml400527n
BindingDB Entry DOI: 10.7270/Q2KS6T3C |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM50020082
(CHEMBL3287871)Show SMILES OC(=O)C[C@H]1CC[C@@H](CC1)c1ccc(cc1)-c1ccc2N(CCOc2c1)S(=O)(=O)Cc1ccccc1 |r,wU:7.10,wD:4.3,(29.7,-15.27,;31.04,-16.03,;32.36,-15.24,;31.06,-17.57,;29.73,-18.35,;28.39,-17.59,;27.07,-18.38,;27.09,-19.92,;28.43,-20.67,;29.75,-19.89,;25.76,-20.7,;24.42,-19.94,;23.1,-20.73,;23.12,-22.27,;24.46,-23.02,;25.78,-22.24,;21.79,-23.05,;21.81,-24.59,;20.49,-25.37,;19.15,-24.62,;17.82,-25.4,;16.48,-24.64,;16.47,-23.1,;17.79,-22.32,;19.13,-23.07,;20.45,-22.29,;17.84,-26.93,;16.35,-26.52,;17.44,-28.4,;19.16,-27.72,;19.12,-29.26,;17.78,-30,;17.75,-31.54,;19.06,-32.34,;20.4,-31.6,;20.44,-30.06,)| Show InChI InChI=1S/C29H31NO5S/c31-29(32)18-21-6-8-23(9-7-21)24-10-12-25(13-11-24)26-14-15-27-28(19-26)35-17-16-30(27)36(33,34)20-22-4-2-1-3-5-22/h1-5,10-15,19,21,23H,6-9,16-18,20H2,(H,31,32)/t21-,23- | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human DGAT1 expressed in Sf9 insect cells using 1,2-dioleoyl-sn-glycerol and [14C]-palmitoyl-CoA substrate by scintillation counting an... |
ACS Med Chem Lett 5: 544-9 (2014)
Article DOI: 10.1021/ml400527n
BindingDB Entry DOI: 10.7270/Q2KS6T3C |
More data for this
Ligand-Target Pair | |
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