new BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Diacylglycerol O-acyltransferase 1 (DGAT1)' and Ligand = 'BDBM50399677'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50399677
PNG
(CHEMBL2178370)
Show SMILES Cc1nc(C)c(nc1C(N)=O)-c1ccc2c(CC[C@@]22CC[C@@H](CC2)c2nnn[nH]2)c1 |r,wD:18.18,21.26,(4.06,-36.56,;5.39,-35.79,;6.73,-36.56,;8.06,-35.79,;9.4,-36.56,;8.06,-34.26,;6.73,-33.48,;5.39,-34.25,;4.06,-33.48,;2.73,-34.25,;4.06,-31.94,;9.39,-33.49,;9.39,-31.94,;10.72,-31.17,;12.06,-31.94,;12.07,-33.48,;13.54,-33.95,;14.44,-32.69,;13.52,-31.45,;12.42,-30.37,;12.82,-28.88,;14.3,-28.47,;15.39,-29.56,;15,-31.04,;14.7,-26.99,;13.72,-25.79,;14.55,-24.5,;16.04,-24.89,;16.13,-26.43,;10.72,-34.26,)|
Show InChI InChI=1S/C22H25N7O/c1-12-18(25-19(20(23)30)13(2)24-12)16-3-4-17-15(11-16)7-10-22(17)8-5-14(6-9-22)21-26-28-29-27-21/h3-4,11,14H,5-10H2,1-2H3,(H2,23,30)(H,26,27,28,29)/t14-,22-
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 120n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DGAT1 expressed in Sf9 cells by liquid scintillography


J Med Chem 55: 10610-29 (2012)


Article DOI: 10.1021/jm301296t
BindingDB Entry DOI: 10.7270/Q2XD12T3
More data for this
Ligand-Target Pair