new BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Diacylglycerol O-acyltransferase 1 (DGAT1)' and Ligand = 'BDBM50399684'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50399684
PNG
(CHEMBL2178944)
Show SMILES Cc1nc(C)c(nc1C(N)=O)-c1ccc(cc1)[C@@H]1CC[C@H](CC(O)=O)CC1 |r,wU:17.18,20.22,(39.9,-10.55,;41.23,-9.78,;42.57,-10.55,;43.9,-9.77,;45.24,-10.54,;43.9,-8.24,;42.57,-7.47,;41.23,-8.23,;39.9,-7.46,;38.56,-8.23,;39.9,-5.92,;45.23,-7.47,;46.56,-8.24,;47.9,-7.47,;47.9,-5.92,;46.56,-5.16,;45.23,-5.93,;49.23,-5.15,;50.57,-5.92,;51.89,-5.15,;51.89,-3.61,;53.23,-2.84,;54.56,-3.61,;55.9,-2.84,;54.56,-5.15,;50.56,-2.84,;49.22,-3.61,)|
Show InChI InChI=1S/C21H25N3O3/c1-12-19(24-20(21(22)27)13(2)23-12)17-9-7-16(8-10-17)15-5-3-14(4-6-15)11-18(25)26/h7-10,14-15H,3-6,11H2,1-2H3,(H2,22,27)(H,25,26)/t14-,15+
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 430n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DGAT1 expressed in Sf9 cells by liquid scintillography


J Med Chem 55: 10610-29 (2012)


Article DOI: 10.1021/jm301296t
BindingDB Entry DOI: 10.7270/Q2XD12T3
More data for this
Ligand-Target Pair