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Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Diacylglycerol O-acyltransferase 2' and Ligand = 'BDBM215526'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM215526
PNG
(US9296745, 82)
Show SMILES O=C([C@@H]1CCCN(C1)c1ccc2nc([nH]c2n1)C1(CC1)c1ccccn1)N1CCCC1 |r|
Show InChI InChI=1/C24H28N6O/c31-22(29-13-3-4-14-29)17-6-5-15-30(16-17)20-9-8-18-21(27-20)28-23(26-18)24(10-11-24)19-7-1-2-12-25-19/h1-2,7-9,12,17H,3-6,10-11,13-16H2,(H,26,27,28)/t17-/s2
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KEGG

UniProtKB/SwissProt

antibodypedia
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PC cid
PC sid
UniChem
US Patent
n/an/a 15.8n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
For evaluation of the effects of DGAT2 inhibitors in a cell-based setting, cryopreserved human hepatocytes (Lot QOC, Celsis, Chicago, Ill.) were thaw...


US Patent US9296745 (2016)


BindingDB Entry DOI: 10.7270/Q25719VW
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM215526
PNG
(US9296745, 82)
Show SMILES O=C([C@@H]1CCCN(C1)c1ccc2nc([nH]c2n1)C1(CC1)c1ccccn1)N1CCCC1 |r|
Show InChI InChI=1/C24H28N6O/c31-22(29-13-3-4-14-29)17-6-5-15-30(16-17)20-9-8-18-21(27-20)28-23(26-18)24(10-11-24)19-7-1-2-12-25-19/h1-2,7-9,12,17H,3-6,10-11,13-16H2,(H,26,27,28)/t17-/s2
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 165n/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 uL. To 1 uL of c...


US Patent US9296745 (2016)


BindingDB Entry DOI: 10.7270/Q25719VW
More data for this
Ligand-Target Pair