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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Diacylglycerol O-acyltransferase 2' and Ligand = 'BDBM215568'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))
BDBM215568
PNG
(US9296745, 124)
Show SMILES CCOC(=O)C1(CC1)c1cccc(c1)-c1nc2ccc(nc2[nH]1)N1CCC[C@H](C1)C(=O)N1CCCC1 |r|
Show InChI InChI=1/C28H33N5O3/c1-2-36-27(35)28(12-13-28)21-9-5-7-19(17-21)24-29-22-10-11-23(30-25(22)31-24)33-16-6-8-20(18-33)26(34)32-14-3-4-15-32/h5,7,9-11,17,20H,2-4,6,8,12-16,18H2,1H3,(H,29,30,31)/t20-/s2
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PC cid
PC sid
UniChem
US Patent
n/an/a 5.27n/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 uL. To 1 uL of c...


US Patent US9296745 (2016)


BindingDB Entry DOI: 10.7270/Q25719VW
More data for this
Ligand-Target Pair