BindingDB PrimarySearch

Found 4 hits Enz. Inhib. hit(s) with Target = 'Dihydrofolate reductase' and Ligand = 'BDBM33401'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Dihydrofolate reductase (Mus musculus (Mouse))	BDBM33401 (2,4-diaminofuro[2,3-d]pyrimidine, 7 \| E/Z ratio=3:...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Standard DHFR assays were conducted at 37 deg C with continuous recording of change of OD at 340 nm. All determinations of IC50 were made by fitting ...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM33401 (2,4-diaminofuro[2,3-d]pyrimidine, 7 \| E/Z ratio=3:...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.64E+3	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Standard DHFR assays were conducted at 37 deg C with continuous recording of change of OD at 340 nm. All determinations of IC50 were made by fitting ...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Dihydrofolate reductase (Rattus norvegicus (rat))	BDBM33401 (2,4-diaminofuro[2,3-d]pyrimidine, 7 \| E/Z ratio=3:...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.64E+3	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Standard DHFR assays were conducted at 37 deg C with continuous recording of change of OD at 340 nm. All determinations of IC50 were made by fitting ...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair
Dihydrofolate reductase (Pneumocystis carinii)	BDBM33401 (2,4-diaminofuro[2,3-d]pyrimidine, 7 \| E/Z ratio=3:...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University					Assay Description Standard DHFR assays were conducted at 37 deg C with continuous recording of change of OD at 340 nm. All determinations of IC50 were made by fitting ...				Bioorg Med Chem 17: 7324-36 (2009) Article DOI: 10.1016/j.bmc.2009.08.044 BindingDB Entry DOI: 10.7270/Q2ZC8167
Duquesne University					More data for this Ligand-Target Pair