Found 3 hits Enz. Inhib. hit(s) with Target = 'Dual specificity mitogen-activated protein kinase kinase 1' and Ligand = 'BDBM50187841' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Dual specificity mitogen-activated protein kinase kinase 1
(Homo sapiens (Human)) | BDBM50187841
(3-hydroxy-5-(4-iodo-2-methylphenylamino)-N-isoprop...)Show InChI InChI=1S/C14H17IN4OS/c1-7(2)17-12(16)11-13(20)19-21-14(11)18-10-5-4-9(15)6-8(10)3/h4-7,18H,1-3H3,(H2,16,17)(H,19,20) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 62 | n/a | n/a | n/a | n/a | n/a | n/a |
Valeant Pharmaceuticals Research & Development
Curated by ChEMBL
| Assay Description Inhibition of MEK-1 activity |
Bioorg Med Chem Lett 16: 5561-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.048 BindingDB Entry DOI: 10.7270/Q2J38S5D |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 1
(Homo sapiens (Human)) | BDBM50187841
(3-hydroxy-5-(4-iodo-2-methylphenylamino)-N-isoprop...)Show InChI InChI=1S/C14H17IN4OS/c1-7(2)17-12(16)11-13(20)19-21-14(11)18-10-5-4-9(15)6-8(10)3/h4-7,18H,1-3H3,(H2,16,17)(H,19,20) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 62 | n/a | n/a | n/a | n/a | n/a | n/a |
Valeant Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description Inhibition of MEK1 |
Bioorg Med Chem Lett 16: 3975-80 (2006)
Article DOI: 10.1016/j.bmcl.2006.05.019 BindingDB Entry DOI: 10.7270/Q2SJ1K6C |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 1
(Homo sapiens (Human)) | BDBM50187841
(3-hydroxy-5-(4-iodo-2-methylphenylamino)-N-isoprop...)Show InChI InChI=1S/C14H17IN4OS/c1-7(2)17-12(16)11-13(20)19-21-14(11)18-10-5-4-9(15)6-8(10)3/h4-7,18H,1-3H3,(H2,16,17)(H,19,20) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 1.48E+3 | n/a | n/a | n/a | n/a |
Valeant Pharmaceuticals Research & Development
Curated by ChEMBL
| Assay Description Inhibitory activity against MEK-1 |
Bioorg Med Chem Lett 16: 5561-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.048 BindingDB Entry DOI: 10.7270/Q2J38S5D |
More data for this Ligand-Target Pair | |