BindingDB PrimarySearch

Found 5 hits Enz. Inhib. hit(s) with Target = 'Dual specificity protein kinase CLK2' and Ligand = 'BDBM317462'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Dual specificity protein kinase CLK2 (Homo sapiens (Human))	BDBM317462 (4-(4-(cyclopentyloxy)-5-(2- methylbenzo[d]oxazol-6...) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Corporation Curated by ChEMBL					Assay Description Inhibition of human GST-tagged CLK2 expressed in baculovirus by Z'-LYTE assay				J Med Chem 60: 8989-9002 (2017) Article DOI: 10.1021/acs.jmedchem.7b01223 BindingDB Entry DOI: 10.7270/Q2GF0WX9
Celgene Corporation Curated by ChEMBL					More data for this Ligand-Target Pair
Dual specificity protein kinase CLK2 (Homo sapiens (Human))	BDBM317462 (4-(4-(cyclopentyloxy)-5-(2- methylbenzo[d]oxazol-6...) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	6.30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1016/j.bmc.2022.116921 BindingDB Entry DOI: 10.7270/Q25B06FX
TBA					More data for this Ligand-Target Pair
Dual specificity protein kinase CLK2 (Homo sapiens (Human))	BDBM317462 (4-(4-(cyclopentyloxy)-5-(2- methylbenzo[d]oxazol-6...) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	US Patent	n/a	n/a	8.17	n/a	n/a	n/a	n/a	n/a	n/a
Signal Pharmaceuticals, LLC US Patent					Assay Description The kinase activity is measured using a radioactivity based kinase assay, which measures the incorporation of a radioactively labeled phosphate moiet...				US Patent US9623028 (2017) BindingDB Entry DOI: 10.7270/Q2VQ34R8
Signal Pharmaceuticals, LLC US Patent					More data for this Ligand-Target Pair
Dual specificity protein kinase CLK2 (Homo sapiens (Human))	BDBM317462 (4-(4-(cyclopentyloxy)-5-(2- methylbenzo[d]oxazol-6...) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Corporation Curated by ChEMBL					Assay Description Inhibition of CLK2 in human HCT116 cell lysate after 1 hr by LC-MS/MS analysis relative to control				J Med Chem 60: 8989-9002 (2017) Article DOI: 10.1021/acs.jmedchem.7b01223 BindingDB Entry DOI: 10.7270/Q2GF0WX9
Celgene Corporation Curated by ChEMBL					More data for this Ligand-Target Pair
Dual specificity protein kinase CLK2 (Homo sapiens (Human))	BDBM317462 (4-(4-(cyclopentyloxy)-5-(2- methylbenzo[d]oxazol-6...) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	549	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Corporation Curated by ChEMBL					Assay Description Inhibition of CLK2 in human CAL51 cells assessed as reduction in phosphorylation of SRp75 after 1 hr by Western blot analysis				J Med Chem 60: 8989-9002 (2017) Article DOI: 10.1021/acs.jmedchem.7b01223 BindingDB Entry DOI: 10.7270/Q2GF0WX9
Celgene Corporation Curated by ChEMBL					More data for this Ligand-Target Pair