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Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Dynamin-2' and Ligand = 'BDBM50423883'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dynamin-2


(Homo sapiens (Human))
BDBM50423883
PNG
(CHEMBL2312430)
Show SMILES CCCCCCCCCCNCc1cn(CCCN(C)C)c2ccccc12
Show InChI InChI=1S/C24H41N3/c1-4-5-6-7-8-9-10-13-17-25-20-22-21-27(19-14-18-26(2)3)24-16-12-11-15-23(22)24/h11-12,15-16,21,25H,4-10,13-14,17-20H2,1-3H3
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MMDB

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CHEMBL
MCE
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.90E+3n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibition of dyn2 in human U2OS cells assessed as clathrin-mediated endocytosis of Tfn after 30 mins


J Med Chem 56: 46-59 (2013)


Article DOI: 10.1021/jm300844m
BindingDB Entry DOI: 10.7270/Q2DJ5GZ3
More data for this
Ligand-Target Pair
Dynamin-2


(Rattus norvegicus)
BDBM50423883
PNG
(CHEMBL2312430)
Show SMILES CCCCCCCCCCNCc1cn(CCCN(C)C)c2ccccc12
Show InChI InChI=1S/C24H41N3/c1-4-5-6-7-8-9-10-13-17-25-20-22-21-27(19-14-18-26(2)3)24-16-12-11-15-23(22)24/h11-12,15-16,21,25H,4-10,13-14,17-20H2,1-3H3
PDB
MMDB

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KEGG

UniProtKB/SwissProt

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CHEMBL
MCE
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 5.40E+3n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Inhibition of rat full length His6-tagged dyn2 using phosphotidylserine as substrate after 90 mins by malachite green GTPase assay in presence of GTP


J Med Chem 56: 46-59 (2013)


Article DOI: 10.1021/jm300844m
BindingDB Entry DOI: 10.7270/Q2DJ5GZ3
More data for this
Ligand-Target Pair