Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'E3 ubiquitin-protein ligase Mdm2' and Ligand = 'BDBM129884'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM129884 (US8815926, 164) Show SMILES COc1nc(ncc1-c1nc2C(=O)N([C@H](c2n1C(C)C)c1ccc(Cl)cc1)c1cc(Cl)cnc1O)N(C)C |r| Show InChI InChI=1S/C26H25Cl2N7O3/c1-13(2)34-21-19(31-22(34)17-12-30-26(33(3)4)32-24(17)38-5)25(37)35(18-10-16(28)11-29-23(18)36)20(21)14-6-8-15(27)9-7-14/h6-13,20H,1-5H3,(H,29,36)/t20-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...				US Patent US8815926 (2014) BindingDB Entry DOI: 10.7270/Q29P309G
					More data for this Ligand-Target Pair