Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'E3 ubiquitin-protein ligase Mdm2' and Ligand = 'BDBM162090'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM162090 (US9051279, 87) Show SMILES COc1cc2CC(=O)N([C@@H](c3ccc(Cl)cc3)c2cc1OC(C)C)c1ccc(cc1)[C@H](C)N1CCS(=O)(=O)CC1 |r| Show InChI InChI=1S/C31H35ClN2O5S/c1-20(2)39-29-19-27-24(17-28(29)38-4)18-30(35)34(31(27)23-5-9-25(32)10-6-23)26-11-7-22(8-12-26)21(3)33-13-15-40(36,37)16-14-33/h5-12,17,19-21,31H,13-16,18H2,1-4H3/t21-,31-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	33.3	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description The inhibition of p53-Hdm2 and p53-Hdm4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...				US Patent US9051279 (2015) BindingDB Entry DOI: 10.7270/Q2DV1HMM
					More data for this Ligand-Target Pair