Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'E3 ubiquitin-protein ligase Mdm2' and Ligand = 'BDBM50007645'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50007645 (CHEMBL3233126) Show SMILES CC[C@@H](CN(c1ccccc1F)S(=O)(=O)C(C)C)N1[C@@H]([C@H](O[C@H](CC(O)=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C31H33Cl2FN2O6S/c1-4-24(18-35(43(40,41)19(2)3)26-11-6-5-10-25(26)34)36-29(20-12-14-22(32)15-13-20)30(21-8-7-9-23(33)16-21)42-27(31(36)39)17-28(37)38/h5-16,19,24,27,29-30H,4,17-18H2,1-3H3,(H,37,38)/t24-,27+,29+,30+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Binding affinity to GST-thrombin-tagged human MDM2 (1 to 188) expressed in Escherichia coli assessed as inhibition of interaction with p53 in serum f...				J Med Chem 57: 2472-88 (2014) Article DOI: 10.1021/jm401767k BindingDB Entry DOI: 10.7270/Q2C24XZZ
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50007645 (CHEMBL3233126) Show SMILES CC[C@@H](CN(c1ccccc1F)S(=O)(=O)C(C)C)N1[C@@H]([C@H](O[C@H](CC(O)=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C31H33Cl2FN2O6S/c1-4-24(18-35(43(40,41)19(2)3)26-11-6-5-10-25(26)34)36-29(20-12-14-22(32)15-13-20)30(21-8-7-9-23(33)16-21)42-27(31(36)39)17-28(37)38/h5-16,19,24,27,29-30H,4,17-18H2,1-3H3,(H,37,38)/t24-,27+,29+,30+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.40	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Binding affinity to GST-thrombin-tagged human MDM2 (1 to 188) expressed in Escherichia coli assessed as inhibition of interaction with p53 in buffer ...				J Med Chem 57: 2472-88 (2014) Article DOI: 10.1021/jm401767k BindingDB Entry DOI: 10.7270/Q2C24XZZ
					More data for this Ligand-Target Pair