Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'E3 ubiquitin-protein ligase Mdm2' and Ligand = 'BDBM50012595'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50012595 (CHEMBL3260812) Show SMILES Cc1cccc(c1)-c1nc(C(O)=O)c(-c2cccc(Cl)c2)n1-c1cc(Cl)ccc1C |(65.23,-4.64,;64.05,-5.63,;64.32,-7.16,;63.14,-8.15,;61.7,-7.62,;61.43,-6.1,;62.61,-5.11,;59.99,-5.57,;59.57,-4.09,;58.02,-4.03,;57.16,-2.75,;57.83,-1.37,;55.62,-2.86,;57.5,-5.48,;55.96,-5.47,;55.19,-6.8,;53.66,-6.8,;52.88,-5.46,;53.66,-4.12,;52.9,-2.79,;55.2,-4.13,;58.71,-6.43,;58.66,-7.96,;59.96,-8.77,;59.91,-10.31,;61.22,-11.12,;58.54,-11.04,;57.24,-10.22,;57.29,-8.68,;55.99,-7.86,)| Show InChI InChI=1S/C24H18Cl2N2O2/c1-14-5-3-7-17(11-14)23-27-21(24(29)30)22(16-6-4-8-18(25)12-16)28(23)20-13-19(26)10-9-15(20)2/h3-13H,1-2H3,(H,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of MDM2 (unknown origin) (2 to 188) assessed as inhibition of p53-MDM2 interaction by TR-FRET assay				Bioorg Med Chem Lett 24: 2110-4 (2014) Article DOI: 10.1016/j.bmcl.2014.03.039 BindingDB Entry DOI: 10.7270/Q2RJ4M1C
					More data for this Ligand-Target Pair				3D Structure (crystal)