BindingDB PrimarySearch

Found 4 hits Enz. Inhib. hit(s) with Target = 'E3 ubiquitin-protein ligase Mdm2' and Ligand = 'BDBM50014092'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50014092 (CHEMBL3259830 \| US9187441, 9l) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	PDB US Patent	300	-36.6	n/a	n/a	n/a	n/a	n/a	n/a	20
University of Pittsburgh—Of the Commonwealth System of Higher Education US Patent					Assay Description Fluorescent polarization experiments were performed as follows. Briefly, the fluorescence polarization experiments were read on an Ultra Evolution 38...				US Patent US9187441 (2015) BindingDB Entry DOI: 10.7270/Q2DR2T9N
					More data for this Ligand-Target Pair				3D Structure (crystal)
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50014092 (CHEMBL3259830 \| US9187441, 9l) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	400	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Utah Curated by ChEMBL					Assay Description Displacement of fluorescent P4 peptide from MDM2 (unknown origin) by fluorescence polarization assay				Bioorg Med Chem Lett 24: 2546-54 (2014) Article DOI: 10.1016/j.bmcl.2014.03.095 BindingDB Entry DOI: 10.7270/Q2FX7C05
University of Utah Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50014092 (CHEMBL3259830 \| US9187441, 9l) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	PDB US Patent	400	-35.9	n/a	n/a	n/a	n/a	n/a	n/a	20
University of Pittsburgh—Of the Commonwealth System of Higher Education US Patent					Assay Description Fluorescent polarization experiments were performed as follows. Briefly, the fluorescence polarization experiments were read on an Ultra Evolution 38...				US Patent US9187441 (2015) BindingDB Entry DOI: 10.7270/Q2DR2T9N
					More data for this Ligand-Target Pair				3D Structure (crystal)
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50014092 (CHEMBL3259830 \| US9187441, 9l) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	PDB US Patent	700	-34.5	n/a	n/a	n/a	n/a	n/a	n/a	20
University of Pittsburgh—Of the Commonwealth System of Higher Education US Patent					Assay Description Fluorescent polarization experiments were performed as follows. Briefly, the fluorescence polarization experiments were read on an Ultra Evolution 38...				US Patent US9187441 (2015) BindingDB Entry DOI: 10.7270/Q2DR2T9N
					More data for this Ligand-Target Pair				3D Structure (crystal)