Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'E3 ubiquitin-protein ligase Mdm2' and Ligand = 'BDBM50339363'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50339363 ((+/-)-trans-3-(4-Chlorophenyl)-3-(4-hydroxymethylc...) Show SMILES OC[C@H]1CC[C@H](COC2(N(Cc3ccc(cc3)[N+]([O-])=O)C(=O)c3ccccc23)c2ccc(Cl)cc2)CC1 |r,wU:5.5,wD:2.1,(-7.05,-6.08,;-8.14,-7.17,;-7.74,-8.66,;-8.83,-9.76,;-8.42,-11.24,;-6.94,-11.63,;-6.54,-13.11,;-5.05,-13.51,;-4.65,-15,;-3.74,-16.26,;-2.2,-16.26,;-1.43,-17.59,;-2.2,-18.92,;-1.43,-20.25,;.11,-20.25,;.88,-18.91,;.11,-17.58,;.89,-21.59,;.12,-22.93,;2.43,-21.59,;-4.65,-17.51,;-4.17,-18.98,;-6.12,-17.03,;-7.45,-17.8,;-8.79,-17.03,;-8.78,-15.49,;-7.46,-14.72,;-6.12,-15.48,;-3.33,-14.21,;-1.98,-14.96,;-.66,-14.17,;-.69,-12.63,;.63,-11.84,;-2.04,-11.88,;-3.36,-12.68,;-5.85,-10.54,;-6.25,-9.06,)| Show InChI InChI=1S/C29H29ClN2O5/c30-24-13-11-23(12-14-24)29(37-19-22-7-5-21(18-33)6-8-22)27-4-2-1-3-26(27)28(34)31(29)17-20-9-15-25(16-10-20)32(35)36/h1-4,9-16,21-22,33H,5-8,17-19H2/t21-,22-,29?	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	580	n/a	n/a	n/a	n/a	n/a	n/a
Newcastle University Curated by ChEMBL					Assay Description Inhibition of Mdm2 -p53 protein interaction by ELISA				J Med Chem 54: 1233-43 (2011) Article DOI: 10.1021/jm1011929 BindingDB Entry DOI: 10.7270/Q29K4BHN
					More data for this Ligand-Target Pair