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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'E3 ubiquitin-protein ligase SMURF1' and Ligand = 'BDBM239098'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
E3 ubiquitin-protein ligase SMURF1


(Homo sapiens (Human))		BDBM239098
PNG
(US10195181, Example 1.7 | US9403810, 1.7)
Show SMILES Cc1c(noc1C1=CCC(CC1)C(F)(F)F)C(=O)Nc1c(C)n(C)n(C2CCCCC2)c1=O |t:7|
Show InChI InChI=1S/C23H29F3N4O3/c1-13-18(28-33-20(13)15-9-11-16(12-10-15)23(24,25)26)21(31)27-19-14(2)29(3)30(22(19)32)17-7-5-4-6-8-17/h9,16-17H,4-8,10-12H2,1-3H3,(H,27,31)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 33n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...

US Patent US10195181 (2019)


BindingDB Entry DOI: 10.7270/Q28054Q2
More data for this
Ligand-Target Pair