Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
E3 ubiquitin-protein ligase SMURF1 (Homo sapiens (Human)) | BDBM239135 (US10195181, Example 24b | US9403810, 24a) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 250 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG US Patent | Assay Description To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1... | US Patent US10195181 (2019) BindingDB Entry DOI: 10.7270/Q28054Q2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
E3 ubiquitin-protein ligase SMURF1 (Homo sapiens (Human)) | BDBM239135 (US10195181, Example 24b | US9403810, 24a) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 340 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG US Patent | Assay Description To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1... | US Patent US10195181 (2019) BindingDB Entry DOI: 10.7270/Q28054Q2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
E3 ubiquitin-protein ligase SMURF1 (Homo sapiens (Human)) | BDBM239135 (US10195181, Example 24b | US9403810, 24a) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 350 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG US Patent | Assay Description To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1... | US Patent US10195181 (2019) BindingDB Entry DOI: 10.7270/Q28054Q2 | |||||||||||
More data for this Ligand-Target Pair |