Compile Data Set for Download or QSAR

Found 6 hits Enz. Inhib. hit(s) with Target = 'Endothelial lipase' and Ligand = 'BDBM50443625'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Endothelial lipase (Mus musculus (Mouse))	BDBM50443625 (CHEMBL3092448 | US9216998, 25) Show SMILES FC(F)(F)c1c(CCc2ccccc2)n2CCOc3cccc1c23 Show InChI InChI=1S/C19H16F3NO/c20-19(21,22)17-14-7-4-8-16-18(14)23(11-12-24-16)15(17)10-9-13-5-2-1-3-6-13/h1-8H,9-12H2	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	31	n/a	n/a	n/a	n/a	n/a	n/a
Therachem Research Medilab (India) Pvt. Ltd. Curated by ChEMBL					Assay Description Inhibition of mouse endothelial lipase using PLAi as substrate measured for 30 mins by cell-based fluorescence assay				ACS Med Chem Lett 4: 1016-7 (2013) Article DOI: 10.1021/ml400361q BindingDB Entry DOI: 10.7270/Q22J6DBG
					More data for this Ligand-Target Pair
Endothelial lipase (Mus musculus (Mouse))	BDBM50443625 (CHEMBL3092448 | US9216998, 25) Show SMILES FC(F)(F)c1c(CCc2ccccc2)n2CCOc3cccc1c23 Show InChI InChI=1S/C19H16F3NO/c20-19(21,22)17-14-7-4-8-16-18(14)23(11-12-24-16)15(17)10-9-13-5-2-1-3-6-13/h1-8H,9-12H2	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	31	n/a	n/a	n/a	n/a	n/a	n/a
University of Calabria Curated by ChEMBL					Assay Description Inhibition of endothelial lipase in mouse cells after 30 mins by fluorescence assay				Eur J Med Chem 151: 121-144 (2018) Article DOI: 10.1016/j.ejmech.2018.03.061 BindingDB Entry DOI: 10.7270/Q2HM5C4Q
					More data for this Ligand-Target Pair
Endothelial lipase (Mus musculus (Mouse))	BDBM50443625 (CHEMBL3092448 | US9216998, 25) Show SMILES FC(F)(F)c1c(CCc2ccccc2)n2CCOc3cccc1c23 Show InChI InChI=1S/C19H16F3NO/c20-19(21,22)17-14-7-4-8-16-18(14)23(11-12-24-16)15(17)10-9-13-5-2-1-3-6-13/h1-8H,9-12H2	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	US Patent	n/a	n/a	31	n/a	n/a	n/a	n/a	7.2	n/a
Janssen Pharmaceutica NV US Patent					Assay Description To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND® 384-well plates (Corning, L...				US Patent US9216998 (2015) BindingDB Entry DOI: 10.7270/Q22N513F
					More data for this Ligand-Target Pair
Endothelial lipase (Homo sapiens (Human))	BDBM50443625 (CHEMBL3092448 | US9216998, 25) Show SMILES FC(F)(F)c1c(CCc2ccccc2)n2CCOc3cccc1c23 Show InChI InChI=1S/C19H16F3NO/c20-19(21,22)17-14-7-4-8-16-18(14)23(11-12-24-16)15(17)10-9-13-5-2-1-3-6-13/h1-8H,9-12H2	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	39	n/a	n/a	n/a	n/a	n/a	n/a
University of Calabria Curated by ChEMBL					Assay Description Inhibition of endothelial lipase in human cells after 30 mins by fluorescence assay				Eur J Med Chem 151: 121-144 (2018) Article DOI: 10.1016/j.ejmech.2018.03.061 BindingDB Entry DOI: 10.7270/Q2HM5C4Q
					More data for this Ligand-Target Pair
Endothelial lipase (Homo sapiens (Human))	BDBM50443625 (CHEMBL3092448 | US9216998, 25) Show SMILES FC(F)(F)c1c(CCc2ccccc2)n2CCOc3cccc1c23 Show InChI InChI=1S/C19H16F3NO/c20-19(21,22)17-14-7-4-8-16-18(14)23(11-12-24-16)15(17)10-9-13-5-2-1-3-6-13/h1-8H,9-12H2	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	39	n/a	n/a	n/a	n/a	n/a	n/a
Therachem Research Medilab (India) Pvt. Ltd. Curated by ChEMBL					Assay Description Inhibition of human endothelial lipase using PLAi as substrate measured for 30 mins by cell-based fluorescence assay				ACS Med Chem Lett 4: 1016-7 (2013) Article DOI: 10.1021/ml400361q BindingDB Entry DOI: 10.7270/Q22J6DBG
					More data for this Ligand-Target Pair
Endothelial lipase (Homo sapiens (Human))	BDBM50443625 (CHEMBL3092448 | US9216998, 25) Show SMILES FC(F)(F)c1c(CCc2ccccc2)n2CCOc3cccc1c23 Show InChI InChI=1S/C19H16F3NO/c20-19(21,22)17-14-7-4-8-16-18(14)23(11-12-24-16)15(17)10-9-13-5-2-1-3-6-13/h1-8H,9-12H2	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	US Patent	n/a	n/a	39	n/a	n/a	n/a	n/a	7.2	n/a
Janssen Pharmaceutica NV US Patent					Assay Description To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND® 384-well plates (Corning, L...				US Patent US9216998 (2015) BindingDB Entry DOI: 10.7270/Q22N513F
					More data for this Ligand-Target Pair