Compile Data Set for Download or QSAR

Found 4 hits Enz. Inhib. hit(s) with Target = 'Epidermal growth factor receptor' and Ligand = 'BDBM270578'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM270578 ((S)-2-(4-(((8-chloro- 4- (neopentylamino) quinazol...) Show SMILES CC(C)(C)CNc1ncnc2c(Cl)cc(NC(c3cn(CC(O)=O)nn3)c3ccccc3Cl)cc12 Show InChI InChI=1S/C24H25Cl2N7O2/c1-24(2,3)12-27-23-16-8-14(9-18(26)21(16)28-13-29-23)30-22(15-6-4-5-7-17(15)25)19-10-33(32-31-19)11-20(34)35/h4-10,13,22,30H,11-12H2,1-3H3,(H,34,35)(H,27,28,29)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. US Patent					Assay Description EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...				US Patent US10577352 (2020) BindingDB Entry DOI: 10.7270/Q20P12D3
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM270578 ((S)-2-(4-(((8-chloro- 4- (neopentylamino) quinazol...) Show SMILES CC(C)(C)CNc1ncnc2c(Cl)cc(NC(c3cn(CC(O)=O)nn3)c3ccccc3Cl)cc12 Show InChI InChI=1S/C24H25Cl2N7O2/c1-24(2,3)12-27-23-16-8-14(9-18(26)21(16)28-13-29-23)30-22(15-6-4-5-7-17(15)25)19-10-33(32-31-19)11-20(34)35/h4-10,13,22,30H,11-12H2,1-3H3,(H,34,35)(H,27,28,29)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	7.0	25
GILEAD SCIENCES, INC. US Patent					Assay Description EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...				US Patent US10059695 (2018) BindingDB Entry DOI: 10.7270/Q2FB54Z6
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM270578 ((S)-2-(4-(((8-chloro- 4- (neopentylamino) quinazol...) Show SMILES CC(C)(C)CNc1ncnc2c(Cl)cc(NC(c3cn(CC(O)=O)nn3)c3ccccc3Cl)cc12 Show InChI InChI=1S/C24H25Cl2N7O2/c1-24(2,3)12-27-23-16-8-14(9-18(26)21(16)28-13-29-23)30-22(15-6-4-5-7-17(15)25)19-10-33(32-31-19)11-20(34)35/h4-10,13,22,30H,11-12H2,1-3H3,(H,34,35)(H,27,28,29)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. US Patent					Assay Description EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...				US Patent US10577352 (2020) BindingDB Entry DOI: 10.7270/Q20P12D3
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM270578 ((S)-2-(4-(((8-chloro- 4- (neopentylamino) quinazol...) Show SMILES CC(C)(C)CNc1ncnc2c(Cl)cc(NC(c3cn(CC(O)=O)nn3)c3ccccc3Cl)cc12 Show InChI InChI=1S/C24H25Cl2N7O2/c1-24(2,3)12-27-23-16-8-14(9-18(26)21(16)28-13-29-23)30-22(15-6-4-5-7-17(15)25)19-10-33(32-31-19)11-20(34)35/h4-10,13,22,30H,11-12H2,1-3H3,(H,34,35)(H,27,28,29)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	7.0	25
GILEAD SCIENCES, INC. US Patent					Assay Description EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...				US Patent US10059695 (2018) BindingDB Entry DOI: 10.7270/Q2FB54Z6
					More data for this Ligand-Target Pair