Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Epidermal growth factor receptor' and Ligand = 'BDBM270595'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM270595 (US10059695, II-1 | US10577352, Compound II-1 | ben...) Show SMILES Fc1ccc(Nc2ncnc3c(Cl)cc(NC(c4cn(nn4)C4CCN(CC4)C(=O)OCc4ccccc4)c4ccccc4)cc23)cc1Cl Show InChI InChI=1S/C36H31Cl2FN8O2/c37-29-18-25(11-12-31(29)39)43-35-28-17-26(19-30(38)34(28)40-22-41-35)42-33(24-9-5-2-6-10-24)32-20-47(45-44-32)27-13-15-46(16-14-27)36(48)49-21-23-7-3-1-4-8-23/h1-12,17-20,22,27,33,42H,13-16,21H2,(H,40,41,43)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8.48E+3	n/a	n/a	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. US Patent					Assay Description EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...				US Patent US10577352 (2020) BindingDB Entry DOI: 10.7270/Q20P12D3
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM270595 (US10059695, II-1 | US10577352, Compound II-1 | ben...) Show SMILES Fc1ccc(Nc2ncnc3c(Cl)cc(NC(c4cn(nn4)C4CCN(CC4)C(=O)OCc4ccccc4)c4ccccc4)cc23)cc1Cl Show InChI InChI=1S/C36H31Cl2FN8O2/c37-29-18-25(11-12-31(29)39)43-35-28-17-26(19-30(38)34(28)40-22-41-35)42-33(24-9-5-2-6-10-24)32-20-47(45-44-32)27-13-15-46(16-14-27)36(48)49-21-23-7-3-1-4-8-23/h1-12,17-20,22,27,33,42H,13-16,21H2,(H,40,41,43)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8.48E+3	n/a	n/a	n/a	n/a	7.0	25
GILEAD SCIENCES, INC. US Patent					Assay Description EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...				US Patent US10059695 (2018) BindingDB Entry DOI: 10.7270/Q2FB54Z6
					More data for this Ligand-Target Pair