BindingDB PrimarySearch

Found 6 hits Enz. Inhib. hit(s) with Target = 'Epidermal growth factor receptor' and Ligand = 'BDBM4313'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM4313 ((2E)-N-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)prop-...) Show SMILES Oc1ccc(\C=C(/C#N)C(=O)NCc2ccccc2)cc1O Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
University of Oxford Curated by ChEMBL					Assay Description Inhibition of EGFR autophosphorylation				Proc Natl Acad Sci USA 104: 20523-8 (2007) Checked by Author Article DOI: 10.1073/pnas.0708800104 BindingDB Entry DOI: 10.7270/Q2DB82RH
University of Oxford Curated by ChEMBL					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM4313 ((2E)-N-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)prop-...) Show SMILES Oc1ccc(\C=C(/C#N)C(=O)NCc2ccccc2)cc1O Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
University of Oregon Curated by ChEMBL					Assay Description Inhibition of Epidermal growth factor receptor autophosphorylation				J Med Chem 42: 3412-20 (1999) Article DOI: 10.1021/jm990199u BindingDB Entry DOI: 10.7270/Q2RR1XFD
University of Oregon Curated by ChEMBL					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM4313 ((2E)-N-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)prop-...) Show SMILES Oc1ccc(\C=C(/C#N)C(=O)NCc2ccccc2)cc1O Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	501	n/a	n/a	n/a	n/a	n/a	n/a
University of Tennessee Health Sciences Center Curated by ChEMBL					Assay Description Inhibitory activity against epidermal growth factor receptor (EGFR)				J Med Chem 46: 4657-68 (2003) Article DOI: 10.1021/jm030065n BindingDB Entry DOI: 10.7270/Q2N58NKR
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM4313 ((2E)-N-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)prop-...) Show SMILES Oc1ccc(\C=C(/C#N)C(=O)NCc2ccccc2)cc1O Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Hebrew University of Jerusalem					Assay Description The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.				J Med Chem 34: 1896-907 (1991) Article DOI: 10.1021/jm00110a022 BindingDB Entry DOI: 10.7270/Q2KW5D7V
Hebrew University of Jerusalem					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM4313 ((2E)-N-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)prop-...) Show SMILES Oc1ccc(\C=C(/C#N)C(=O)NCc2ccccc2)cc1O Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of EGFR in human A431 cells				J Nat Prod 55: 1529-1560 (1992) Article DOI: 10.1021/np50089a001 BindingDB Entry DOI: 10.7270/Q2J966CC
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM4313 ((2E)-N-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)prop-...) Show SMILES Oc1ccc(\C=C(/C#N)C(=O)NCc2ccccc2)cc1O Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	7.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Allergan Inc. Curated by ChEMBL					Assay Description Inhibition of EGF-dependent proliferation of human and guinea pig keratinocytes; range 7-15 uM				J Med Chem 44: 281-97 (2001) BindingDB Entry DOI: 10.7270/Q2NP2541
Allergan Inc. Curated by ChEMBL					More data for this Ligand-Target Pair