Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Fatty acid synthase (Homo sapiens (Human)) | BDBM119133 ((S)-4-(4-(Benzofuran-5-yl)phenyl)-3-((1-(cycloprop...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 7.70 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline | Assay Description Inhibition of FAS by GSK2194069 was measured by an endpoint assay for thiols using a fluorescent maleimide. | Nat Chem Biol 10: 774-9 (2014) Article DOI: 10.1038/nchembio.1603 BindingDB Entry DOI: 10.7270/Q2FJ2FGK | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Fatty acid synthase (Homo sapiens (Human)) | BDBM119133 ((S)-4-(4-(Benzofuran-5-yl)phenyl)-3-((1-(cycloprop...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem Similars | PDB US Patent | n/a | n/a | 10 | n/a | n/a | n/a | n/a | 7.0 | n/a |
GlaxoSmithKline LLC US Patent | Assay Description Assay #1:Inhibition of FAS activity can be measured based on the detection of residual NADPH substrate after the FAS assay is quenched. This assay is... | US Patent US8802864 (2014) BindingDB Entry DOI: 10.7270/Q2N58K26 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |