Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Fatty acid synthase (Homo sapiens (Human)) | BDBM50241313 ((5R)-4-hydroxy-3,5-dimethyl-5-[(1E)-2-methylbuta-1...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 9.98E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Johns Hopkins University Curated by ChEMBL | Assay Description Inhibitory concentration against purified human fatty acid synthase activity in ZR-75-1 breast cancer cells | J Med Chem 48: 946-61 (2005) Article DOI: 10.1021/jm049389h BindingDB Entry DOI: 10.7270/Q2NS0XN4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Fatty acid synthase (Homo sapiens (Human)) | BDBM50241313 ((5R)-4-hydroxy-3,5-dimethyl-5-[(1E)-2-methylbuta-1...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Allergy and Infectious Diseases Curated by ChEMBL | Assay Description Inhibitory activity against human FAS1 | J Med Chem 49: 159-71 (2006) Article DOI: 10.1021/jm050825p BindingDB Entry DOI: 10.7270/Q2NG4RDB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Fatty acid synthase (Homo sapiens (Human)) | BDBM50241313 ((5R)-4-hydroxy-3,5-dimethyl-5-[(1E)-2-methylbuta-1...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Johns Hopkins University Curated by ChEMBL | Assay Description Inhibitory concentration against purified human fatty acid synthase activity in ZR-75-1 breast cancer cells | J Med Chem 48: 946-61 (2005) Article DOI: 10.1021/jm049389h BindingDB Entry DOI: 10.7270/Q2NS0XN4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Fatty acid synthase (Homo sapiens (Human)) | BDBM50241313 ((5R)-4-hydroxy-3,5-dimethyl-5-[(1E)-2-methylbuta-1...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | >3.80E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Wayne State University Curated by ChEMBL | Assay Description Inhibition of FASN in human HepG2 cells | J Med Chem 54: 5615-38 (2011) Article DOI: 10.1021/jm2005805 BindingDB Entry DOI: 10.7270/Q21N8261 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Fatty acid synthase (Rattus norvegicus) | BDBM50241313 ((5R)-4-hydroxy-3,5-dimethyl-5-[(1E)-2-methylbuta-1...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | >9.51E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Wayne State University Curated by ChEMBL | Assay Description Inhibition of FASN in rat liver | J Med Chem 54: 5615-38 (2011) Article DOI: 10.1021/jm2005805 BindingDB Entry DOI: 10.7270/Q21N8261 | |||||||||||
More data for this Ligand-Target Pair |