Found 4 hits Enz. Inhib. hit(s) with Target = 'Fibroblast growth factor receptor 1' and Ligand = 'BDBM286987' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM286987
(8-(3-(4-acryloylpiperazin-1-yl)propyl)-2-((cyclopr...)Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(NCC3CC3)nc2n(CCCN2CCN(CC2)C(=O)C=C)c1=O |(2.77,8.47,;4.1,7.7,;4.1,6.16,;5.44,5.39,;5.44,3.85,;6.77,3.08,;8.11,3.85,;4.1,3.08,;4.1,1.54,;2.77,3.85,;2.77,5.39,;1.44,6.16,;1.44,3.08,;.1,3.85,;-1.23,3.08,;-2.56,3.85,;-3.9,3.08,;-3.9,1.54,;-5.23,.77,;-5.23,-.77,;-6.57,-1.54,;-8.11,-1.54,;-7.34,-2.87,;-2.56,.77,;-1.23,1.54,;.1,.77,;.1,-.77,;1.44,-1.54,;1.44,-3.08,;2.77,-3.85,;2.77,-5.39,;4.1,-6.16,;5.44,-5.39,;5.44,-3.85,;4.1,-3.08,;6.77,-6.16,;8.11,-5.39,;6.77,-7.7,;8.11,-8.47,;1.44,1.54,;2.77,.77,)| Show InChI InChI=1S/C29H34Cl2N6O4/c1-4-23(38)36-12-10-35(11-13-36)8-5-9-37-27-19(17-33-29(34-27)32-16-18-6-7-18)14-20(28(37)39)24-25(30)21(40-2)15-22(41-3)26(24)31/h4,14-15,17-18H,1,5-13,16H2,2-3H3,(H,32,33,34) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 0.100 | n/a | n/a | n/a | n/a | n/a | 25 |
Principia Biopharma, Inc.
US Patent
| Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin... |
US Patent US9567334 (2017)
BindingDB Entry DOI: 10.7270/Q2XK8HKQ |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM286987
(8-(3-(4-acryloylpiperazin-1-yl)propyl)-2-((cyclopr...)Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(NCC3CC3)nc2n(CCCN2CCN(CC2)C(=O)C=C)c1=O |(2.77,8.47,;4.1,7.7,;4.1,6.16,;5.44,5.39,;5.44,3.85,;6.77,3.08,;8.11,3.85,;4.1,3.08,;4.1,1.54,;2.77,3.85,;2.77,5.39,;1.44,6.16,;1.44,3.08,;.1,3.85,;-1.23,3.08,;-2.56,3.85,;-3.9,3.08,;-3.9,1.54,;-5.23,.77,;-5.23,-.77,;-6.57,-1.54,;-8.11,-1.54,;-7.34,-2.87,;-2.56,.77,;-1.23,1.54,;.1,.77,;.1,-.77,;1.44,-1.54,;1.44,-3.08,;2.77,-3.85,;2.77,-5.39,;4.1,-6.16,;5.44,-5.39,;5.44,-3.85,;4.1,-3.08,;6.77,-6.16,;8.11,-5.39,;6.77,-7.7,;8.11,-8.47,;1.44,1.54,;2.77,.77,)| Show InChI InChI=1S/C29H34Cl2N6O4/c1-4-23(38)36-12-10-35(11-13-36)8-5-9-37-27-19(17-33-29(34-27)32-16-18-6-7-18)14-20(28(37)39)24-25(30)21(40-2)15-22(41-3)26(24)31/h4,14-15,17-18H,1,5-13,16H2,2-3H3,(H,32,33,34) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2DB850W |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM286987
(8-(3-(4-acryloylpiperazin-1-yl)propyl)-2-((cyclopr...)Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(NCC3CC3)nc2n(CCCN2CCN(CC2)C(=O)C=C)c1=O |(2.77,8.47,;4.1,7.7,;4.1,6.16,;5.44,5.39,;5.44,3.85,;6.77,3.08,;8.11,3.85,;4.1,3.08,;4.1,1.54,;2.77,3.85,;2.77,5.39,;1.44,6.16,;1.44,3.08,;.1,3.85,;-1.23,3.08,;-2.56,3.85,;-3.9,3.08,;-3.9,1.54,;-5.23,.77,;-5.23,-.77,;-6.57,-1.54,;-8.11,-1.54,;-7.34,-2.87,;-2.56,.77,;-1.23,1.54,;.1,.77,;.1,-.77,;1.44,-1.54,;1.44,-3.08,;2.77,-3.85,;2.77,-5.39,;4.1,-6.16,;5.44,-5.39,;5.44,-3.85,;4.1,-3.08,;6.77,-6.16,;8.11,-5.39,;6.77,-7.7,;8.11,-8.47,;1.44,1.54,;2.77,.77,)| Show InChI InChI=1S/C29H34Cl2N6O4/c1-4-23(38)36-12-10-35(11-13-36)8-5-9-37-27-19(17-33-29(34-27)32-16-18-6-7-18)14-20(28(37)39)24-25(30)21(40-2)15-22(41-3)26(24)31/h4,14-15,17-18H,1,5-13,16H2,2-3H3,(H,32,33,34) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals Inc.
| Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin... |
Bioorg Med Chem Lett 19: 773-7 (2009)
BindingDB Entry DOI: 10.7270/Q2GX4DVZ |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM286987
(8-(3-(4-acryloylpiperazin-1-yl)propyl)-2-((cyclopr...)Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(NCC3CC3)nc2n(CCCN2CCN(CC2)C(=O)C=C)c1=O |(2.77,8.47,;4.1,7.7,;4.1,6.16,;5.44,5.39,;5.44,3.85,;6.77,3.08,;8.11,3.85,;4.1,3.08,;4.1,1.54,;2.77,3.85,;2.77,5.39,;1.44,6.16,;1.44,3.08,;.1,3.85,;-1.23,3.08,;-2.56,3.85,;-3.9,3.08,;-3.9,1.54,;-5.23,.77,;-5.23,-.77,;-6.57,-1.54,;-8.11,-1.54,;-7.34,-2.87,;-2.56,.77,;-1.23,1.54,;.1,.77,;.1,-.77,;1.44,-1.54,;1.44,-3.08,;2.77,-3.85,;2.77,-5.39,;4.1,-6.16,;5.44,-5.39,;5.44,-3.85,;4.1,-3.08,;6.77,-6.16,;8.11,-5.39,;6.77,-7.7,;8.11,-8.47,;1.44,1.54,;2.77,.77,)| Show InChI InChI=1S/C29H34Cl2N6O4/c1-4-23(38)36-12-10-35(11-13-36)8-5-9-37-27-19(17-33-29(34-27)32-16-18-6-7-18)14-20(28(37)39)24-25(30)21(40-2)15-22(41-3)26(24)31/h4,14-15,17-18H,1,5-13,16H2,2-3H3,(H,32,33,34) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 3.30 | n/a | n/a | n/a | n/a | n/a | n/a |
PRINCIPIA BIOPHARMA, INC.
US Patent
| Assay Description A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin... |
US Patent US9815834 (2017)
BindingDB Entry DOI: 10.7270/Q2B85B83 |
More data for this Ligand-Target Pair | |