BindingDB PrimarySearch

Found 2 hits Enz. Inhib. hit(s) with Target = 'Fibroblast growth factor receptor 1' and Ligand = 'BDBM4651'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM4651 (N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[2-(1H-1,2,...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	25
AstraZeneca					Assay Description An ELISA assay was used to determine the ability of inhibitor to inhibit FGFR-1 TK activity. The compounds were incubated with enzyme 20 min at room ...				J Med Chem 45: 1300-12 (2002) Article DOI: 10.1021/jm011022e BindingDB Entry DOI: 10.7270/Q29C6VMW
AstraZeneca					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM4651 (N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[2-(1H-1,2,...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	25
AstraZeneca					Assay Description An ELISA assay was used to determine the ability of inhibitor to inhibit FGFR-1 TK activity. The compounds were incubated with enzyme 20 min at room ...				J Med Chem 42: 5369-89 (1999) Article DOI: 10.1021/jm990345w BindingDB Entry DOI: 10.7270/Q2F47MBM
AstraZeneca					More data for this Ligand-Target Pair