BindingDB PrimarySearch

Found 7 hits Enz. Inhib. hit(s) with Target = 'Fibroblast growth factor receptor 1' and Ligand = 'BDBM4882'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM4882 ((Z)-3-[(3-(2-Carboxyethyl)-4-methylpyrrol-2-yl)met...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
SUGEN, Inc.					Assay Description The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...				J Med Chem 42: 5120-30 (1999) Article DOI: 10.1021/jm9904295 BindingDB Entry DOI: 10.7270/Q20Z71GM
SUGEN, Inc.					More data for this Ligand-Target Pair				3D Structure (crystal)
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM4882 ((Z)-3-[(3-(2-Carboxyethyl)-4-methylpyrrol-2-yl)met...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
SUGEN, Inc.					Assay Description The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...				J Med Chem 43: 2655-63 (2000) Article DOI: 10.1021/jm9906116 BindingDB Entry DOI: 10.7270/Q2W66J0N
SUGEN, Inc.					More data for this Ligand-Target Pair				3D Structure (crystal)
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM4882 ((Z)-3-[(3-(2-Carboxyethyl)-4-methylpyrrol-2-yl)met...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	n/a	n/a	334	n/a	n/a	n/a	n/a	n/a	n/a
East China University of Science and Technology Curated by ChEMBL					Assay Description Inhibition of FGFR1 using poly(Glu-Tyr)4:1 as substrate after 60 mins by ELISA				J Med Chem 54: 3732-45 (2011) Article DOI: 10.1021/jm200258t BindingDB Entry DOI: 10.7270/Q29W0FTH
					More data for this Ligand-Target Pair				3D Structure (crystal)
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM4882 ((Z)-3-[(3-(2-Carboxyethyl)-4-methylpyrrol-2-yl)met...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
The First Affiliated Hospital of Zhengzhou University Curated by ChEMBL					Assay Description Inhibition of FGFR1 kinase domain (unknown origin)				Eur J Med Chem 126: 476-490 (2017) Article DOI: 10.1016/j.ejmech.2016.11.052 BindingDB Entry DOI: 10.7270/Q2445PQT
					More data for this Ligand-Target Pair				3D Structure (crystal)
Fibroblast growth factor receptor 1 (Mus musculus)	BDBM4882 ((Z)-3-[(3-(2-Carboxyethyl)-4-methylpyrrol-2-yl)met...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
The First Affiliated Hospital of Zhengzhou University Curated by ChEMBL					Assay Description Inhibition of FGF induced FGFR1 autophosphorylation in mouse NIH 3T3 cells preincubated for 5 mins followed by FGF-stimulation for 5 mins in presence...				Eur J Med Chem 126: 476-490 (2017) Article DOI: 10.1016/j.ejmech.2016.11.052 BindingDB Entry DOI: 10.7270/Q2445PQT
					More data for this Ligand-Target Pair				3D Structure (crystal)
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM4882 ((Z)-3-[(3-(2-Carboxyethyl)-4-methylpyrrol-2-yl)met...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB PubMed	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
New York University Medical Center Curated by ChEMBL					Assay Description Inhibition of FGFR1K (unknown origin) autophosphorylation activity assessed as [32P] incorporation				Science 276: 955-60 (1997) BindingDB Entry DOI: 10.7270/Q22Z159C
New York University Medical Center Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Fibroblast growth factor receptor 1 (Mus musculus)	BDBM4882 ((Z)-3-[(3-(2-Carboxyethyl)-4-methylpyrrol-2-yl)met...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB PubMed	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
New York University Medical Center Curated by ChEMBL					Assay Description Inhibition of acidic FGF-stimulated FGFR1 tyrosine autophosphorylation in mouse NIH/3T3 cells by immunoblotting				Science 276: 955-60 (1997) BindingDB Entry DOI: 10.7270/Q22Z159C
New York University Medical Center Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)