BindingDB PrimarySearch

Found 7 hits Enz. Inhib. hit(s) with Target = 'Fibroblast growth factor receptor 2' and Ligand = 'BDBM50355393'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Fibroblast growth factor receptor 2 (Homo sapiens (Human))	BDBM50355393 (BGJ398 \| CHEMBL1834657 \| US9434697, BGJ398 \| US973...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	<0.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01776 BindingDB Entry DOI: 10.7270/Q2765KCQ
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Fibroblast growth factor receptor 2 (Homo sapiens (Human))	BDBM50355393 (BGJ398 \| CHEMBL1834657 \| US9434697, BGJ398 \| US973...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	0.680	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01776 BindingDB Entry DOI: 10.7270/Q2765KCQ
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Fibroblast growth factor receptor 2 (Homo sapiens (Human))	BDBM50355393 (BGJ398 \| CHEMBL1834657 \| US9434697, BGJ398 \| US973...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
The First Affiliated Hospital of Zhengzhou University Curated by ChEMBL					Assay Description Inhibition of recombinant FGFR2 (unknown origin) using peptidic substrates in presence of ATP by Kinase-Glo luminescent kinase assay				Eur J Med Chem 126: 476-490 (2017) Article DOI: 10.1016/j.ejmech.2016.11.052 BindingDB Entry DOI: 10.7270/Q2445PQT
					More data for this Ligand-Target Pair				3D Structure (crystal)
Fibroblast growth factor receptor 2 (Homo sapiens (Human))	BDBM50355393 (BGJ398 \| CHEMBL1834657 \| US9434697, BGJ398 \| US973...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institute for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of recombinant FGFR2				J Med Chem 54: 7066-83 (2011) Article DOI: 10.1021/jm2006222 BindingDB Entry DOI: 10.7270/Q22N52N1
					More data for this Ligand-Target Pair				3D Structure (crystal)
Fibroblast growth factor receptor 2 (Homo sapiens (Human))	BDBM50355393 (BGJ398 \| CHEMBL1834657 \| US9434697, BGJ398 \| US973...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of FGFR2 (unknown origin)				Citation and Details Article DOI: 10.1016/j.ejmech.2021.113499 BindingDB Entry DOI: 10.7270/Q2HH6PWN
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Fibroblast growth factor receptor 2 (Homo sapiens (Human))	BDBM50355393 (BGJ398 \| CHEMBL1834657 \| US9434697, BGJ398 \| US973...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institute for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of FGFR2 juxtamembrane domain-mediated proliferation of mouse BAF3 cells transformed with TEL-Kinase construct				J Med Chem 54: 7066-83 (2011) Article DOI: 10.1021/jm2006222 BindingDB Entry DOI: 10.7270/Q22N52N1
					More data for this Ligand-Target Pair				3D Structure (crystal)
Fibroblast growth factor receptor 2 (Homo sapiens (Human))	BDBM50355393 (BGJ398 \| CHEMBL1834657 \| US9434697, BGJ398 \| US973...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	4.90	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institute for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of wild type FGFR2 expressed in HEK293 cells assessed as inhibition of autophosphorylation of tyrosine residue after 40 mins by ELISA assa...				J Med Chem 54: 7066-83 (2011) Article DOI: 10.1021/jm2006222 BindingDB Entry DOI: 10.7270/Q22N52N1
					More data for this Ligand-Target Pair				3D Structure (crystal)