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Found 1 hit Enz. Inhib. hit(s) with Target = 'Focal adhesion kinase 1' and Ligand = 'BDBM50246137'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Focal adhesion kinase 1


(Homo sapiens (Human))		BDBM50246137
PNG
(5-(5-bromo-4-(pyridin-2-ylmethylamino)pyrimidin-2-...)
Show SMILES Brc1cnc(Nc2ccc3NC(=O)Cc3c2)nc1NCc1ccccn1
Show InChI InChI=1S/C18H15BrN6O/c19-14-10-22-18(25-17(14)21-9-13-3-1-2-6-20-13)23-12-4-5-15-11(7-12)8-16(26)24-15/h1-7,10H,8-9H2,(H,24,26)(H2,21,22,23,25)
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n/an/a 46n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged FAK (unknown origin) assessed as inhibition of poly-Glu-Tyr phosphorylation

Bioorg Med Chem Lett 18: 6071-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.10.030
BindingDB Entry DOI: 10.7270/Q2C8295H
More data for this
Ligand-Target Pair