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Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Focal adhesion kinase 1' and Ligand = 'BDBM50361212'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Focal adhesion kinase 1


(Homo sapiens (Human))
BDBM50361212
PNG
(CHEMBL1934341)
Show SMILES NC(=O)CN1CCC(CC1)c1ccc(Nc2ncc3ccc(-c4cccc(CO)c4)n3n2)cc1
Show InChI InChI=1S/C26H28N6O2/c27-25(34)16-31-12-10-20(11-13-31)19-4-6-22(7-5-19)29-26-28-15-23-8-9-24(32(23)30-26)21-3-1-2-18(14-21)17-33/h1-9,14-15,20,33H,10-13,16-17H2,(H2,27,34)(H,29,30)
PDB
MMDB

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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 33n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FAK expressed in baculovirus expression system after 30 mins by time resolved fluorescence assay


Bioorg Med Chem Lett 22: 133-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.049
BindingDB Entry DOI: 10.7270/Q2C829R4
More data for this
Ligand-Target Pair
Focal adhesion kinase 1


(Homo sapiens (Human))
BDBM50361212
PNG
(CHEMBL1934341)
Show SMILES NC(=O)CN1CCC(CC1)c1ccc(Nc2ncc3ccc(-c4cccc(CO)c4)n3n2)cc1
Show InChI InChI=1S/C26H28N6O2/c27-25(34)16-31-12-10-20(11-13-31)19-4-6-22(7-5-19)29-26-28-15-23-8-9-24(32(23)30-26)21-3-1-2-18(14-21)17-33/h1-9,14-15,20,33H,10-13,16-17H2,(H2,27,34)(H,29,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.39E+3n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of FAK in human 293GT cells after 1 hr by luminescence-based spectrophotometry


Bioorg Med Chem Lett 22: 133-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.049
BindingDB Entry DOI: 10.7270/Q2C829R4
More data for this
Ligand-Target Pair