BindingDB PrimarySearch

Found 5 hits Enz. Inhib. hit(s) with Target = 'GTPase KRas' and Ligand = 'BDBM50436053'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
GTPase KRas (Homo sapiens (Human))	BDBM50436053 (CHEMBL2396992) Show SMILES Cc1[nH]c2cc(Cl)cc(Cl)c2c1CCN Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	1.55E+5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of KRas (unknown origin) by nucleotide release assay				Bioorg Med Chem Lett 25: 2461-8 (2015) Article DOI: 10.1016/j.bmcl.2015.04.089 BindingDB Entry DOI: 10.7270/Q2SF2XVC
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
GTPase KRas (Homo sapiens (Human))	BDBM50436053 (CHEMBL2396992) Show SMILES Cc1[nH]c2cc(Cl)cc(Cl)c2c1CCN Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	1.55E+5	n/a	n/a	n/a	n/a	n/a	n/a
The University of Arizona Curated by ChEMBL					Assay Description Inhibition of full-length human KRas4B (amino acids 1 to 188)-SOS interaction assessed as inhibition of SOS-mediated nucleotide release activity				J Med Chem 56: 5219-30 (2014) Article DOI: 10.1021/jm3017706 BindingDB Entry DOI: 10.7270/Q2GB25F2
The University of Arizona Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
GTPase KRas (Homo sapiens (Human))	BDBM50436053 (CHEMBL2396992) Show SMILES Cc1[nH]c2cc(Cl)cc(Cl)c2c1CCN Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	3.42E+5	n/a	n/a	n/a	n/a	n/a	n/a
The University of Arizona Curated by ChEMBL					Assay Description Inhibition of full-length human KRas4B (amino acids 1 to 188)-SOS interaction assessed as inhibition of nucleotide exchange activity				J Med Chem 56: 5219-30 (2014) Article DOI: 10.1021/jm3017706 BindingDB Entry DOI: 10.7270/Q2GB25F2
The University of Arizona Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
GTPase KRas (Homo sapiens (Human))	BDBM50436053 (CHEMBL2396992) Show SMILES Cc1[nH]c2cc(Cl)cc(Cl)c2c1CCN Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	n/a	n/a	1.58E+4	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of KRas activation in HEK 293T-REx Flp-In cells harboring Venus-RBD-CRD/mCherry-CAAX assessed as reduction in Venus-RBD-CRD recruitment to...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01312 BindingDB Entry DOI: 10.7270/Q2T1578S
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
GTPase KRas (Homo sapiens (Human))	BDBM50436053 (CHEMBL2396992) Show SMILES Cc1[nH]c2cc(Cl)cc(Cl)c2c1CCN Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	n/a	1.10E+6	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1016/j.ejmech.2020.113006 BindingDB Entry DOI: 10.7270/Q2G44VBP
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)