Found 3 hits Enz. Inhib. hit(s) with Target = 'Gamma-aminobutyric acid type B receptor subunit 1' and Ligand = 'BDBM86283' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Gamma-aminobutyric acid type B receptor subunit 1
(Rattus norvegicus (Rat)) | BDBM86283
(CAS_345-78-8 | CAS_39069-52-8 | GS 39783 | N,N'...)Show SMILES CSc1nc(NC2CCCC2)c(c(NC2CCCC2)n1)[N+]([O-])=O Show InChI InChI=1S/C15H23N5O2S/c1-23-15-18-13(16-10-6-2-3-7-10)12(20(21)22)14(19-15)17-11-8-4-5-9-11/h10-11H,2-9H2,1H3,(H2,16,17,18,19) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
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MCE PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| 2.75 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Pharma AG
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 307: 322-30 (2003)
Article DOI: 10.1124/jpet.103.053074 BindingDB Entry DOI: 10.7270/Q2542M50 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Gamma-aminobutyric acid type B receptor subunit 1
(Rattus norvegicus (Rat)) | BDBM86283
(CAS_345-78-8 | CAS_39069-52-8 | GS 39783 | N,N'...)Show SMILES CSc1nc(NC2CCCC2)c(c(NC2CCCC2)n1)[N+]([O-])=O Show InChI InChI=1S/C15H23N5O2S/c1-23-15-18-13(16-10-6-2-3-7-10)12(20(21)22)14(19-15)17-11-8-4-5-9-11/h10-11H,2-9H2,1H3,(H2,16,17,18,19) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| 32.4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Pharma AG
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 307: 322-30 (2003)
Article DOI: 10.1124/jpet.103.053074 BindingDB Entry DOI: 10.7270/Q2542M50 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Gamma-aminobutyric acid type B receptor subunit 1
(Homo sapiens (Human)) | BDBM86283
(CAS_345-78-8 | CAS_39069-52-8 | GS 39783 | N,N'...)Show SMILES CSc1nc(NC2CCCC2)c(c(NC2CCCC2)n1)[N+]([O-])=O Show InChI InChI=1S/C15H23N5O2S/c1-23-15-18-13(16-10-6-2-3-7-10)12(20(21)22)14(19-15)17-11-8-4-5-9-11/h10-11H,2-9H2,1H3,(H2,16,17,18,19) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | n/a | n/a | 79 | n/a | n/a | n/a | n/a |
IntelliSyn Pharma
Curated by ChEMBL
| Assay Description Positive allosteric modulation at human GABA-B 1b expressed in CHO cells co-expressing rat GABA-B2 assessed as potentiation of GABA-induced inhibitio... |
Bioorg Med Chem Lett 27: 2239-2258 (2017)
Article DOI: 10.1016/j.bmcl.2017.03.084 BindingDB Entry DOI: 10.7270/Q2VT1VJJ |
More data for this Ligand-Target Pair | 3D Structure (crystal) |