new BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 3 hits Enz. Inhib. hit(s) with Target = 'Ghrelin receptor' and Ligand = 'BDBM50379308'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Ghrelin receptor


(Homo sapiens (Human))
BDBM50379308
PNG
(CHEMBL2011816)
Show SMILES CC(C)[C@@H](N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O)C(=O)NC1CCN(Cc2ccccc2)CC1 |r|
Show InChI InChI=1S/C32H36N4O4/c1-22(2)30(31(38)33-24-15-17-35(18-16-24)20-23-9-5-3-6-10-23)36-21-29(37)34-28-14-13-26(19-27(28)32(36)39)40-25-11-7-4-8-12-25/h3-14,19,22,24,30H,15-18,20-21H2,1-2H3,(H,33,38)(H,34,37)/t30-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
4.40n/an/an/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]Ghrelin from human GHSR1a receptor


Bioorg Med Chem Lett 22: 2046-51 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.014
BindingDB Entry DOI: 10.7270/Q21J9BRV
More data for this
Ligand-Target Pair
Ghrelin receptor


(Homo sapiens (Human))
BDBM50379308
PNG
(CHEMBL2011816)
Show SMILES CC(C)[C@@H](N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O)C(=O)NC1CCN(Cc2ccccc2)CC1 |r|
Show InChI InChI=1S/C32H36N4O4/c1-22(2)30(31(38)33-24-15-17-35(18-16-24)20-23-9-5-3-6-10-23)36-21-29(37)34-28-14-13-26(19-27(28)32(36)39)40-25-11-7-4-8-12-25/h3-14,19,22,24,30H,15-18,20-21H2,1-2H3,(H,33,38)(H,34,37)/t30-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 7n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at mouse GHSR1 receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay


Bioorg Med Chem Lett 22: 2046-51 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.014
BindingDB Entry DOI: 10.7270/Q21J9BRV
More data for this
Ligand-Target Pair
Ghrelin receptor


(Homo sapiens (Human))
BDBM50379308
PNG
(CHEMBL2011816)
Show SMILES CC(C)[C@@H](N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O)C(=O)NC1CCN(Cc2ccccc2)CC1 |r|
Show InChI InChI=1S/C32H36N4O4/c1-22(2)30(31(38)33-24-15-17-35(18-16-24)20-23-9-5-3-6-10-23)36-21-29(37)34-28-14-13-26(19-27(28)32(36)39)40-25-11-7-4-8-12-25/h3-14,19,22,24,30H,15-18,20-21H2,1-2H3,(H,33,38)(H,34,37)/t30-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 8n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay


Bioorg Med Chem Lett 22: 2046-51 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.014
BindingDB Entry DOI: 10.7270/Q21J9BRV
More data for this
Ligand-Target Pair