Found 3 hits Enz. Inhib. hit(s) with Target = 'Glucagon receptor' and Ligand = 'BDBM50007224' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Glucagon receptor
(Homo sapiens (Human)) | BDBM50007224
(CHEMBL3238216)Show SMILES CC(C)(C)CC[C@@H](N1C(=O)C(=N[C@@]11CC[C@@H](CC1)C(C)(C)C)c1cc(F)cc(Cl)c1)c1ccc(cc1)C(=O)NCc1nn[nH]n1 |r,wU:15.19,6.5,wD:12.13,c:10,(7.31,-14.38,;7.3,-12.84,;5.95,-12.09,;5.96,-13.59,;8.62,-12.05,;8.6,-10.51,;9.93,-9.73,;9.87,-8.19,;11.08,-7.24,;12.56,-7.66,;10.55,-5.79,;9.01,-5.85,;8.59,-7.33,;7.4,-6.35,;5.96,-6.88,;5.7,-8.4,;6.88,-9.38,;8.33,-8.85,;4.26,-8.93,;3.07,-7.94,;2.81,-9.46,;3.99,-10.45,;11.33,-4.46,;12.87,-4.48,;13.64,-3.15,;15.18,-3.15,;12.88,-1.8,;11.34,-1.8,;10.57,-.46,;10.56,-3.13,;11.25,-10.51,;11.23,-12.06,;12.55,-12.84,;13.9,-12.09,;13.92,-10.55,;12.6,-9.77,;15.22,-12.88,;15.2,-14.42,;16.56,-12.13,;17.89,-12.91,;19.23,-12.16,;20.63,-12.8,;21.67,-11.66,;20.91,-10.32,;19.4,-10.62,)| Show InChI InChI=1S/C34H43ClFN7O2/c1-32(2,3)14-13-27(21-7-9-22(10-8-21)30(44)37-20-28-39-41-42-40-28)43-31(45)29(23-17-25(35)19-26(36)18-23)38-34(43)15-11-24(12-16-34)33(4,5)6/h7-10,17-19,24,27H,11-16,20H2,1-6H3,(H,37,44)(H,39,40,41,42)/t24-,27-,34-/m1/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Displacement of [125I]-glucagon from recombinant human GCGR expressed in CHO cells after 60 mins by scintillation counting analysis |
J Med Chem 57: 2601-10 (2014)
Article DOI: 10.1021/jm401858f
BindingDB Entry DOI: 10.7270/Q20V8F9P |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM50007224
(CHEMBL3238216)Show SMILES CC(C)(C)CC[C@@H](N1C(=O)C(=N[C@@]11CC[C@@H](CC1)C(C)(C)C)c1cc(F)cc(Cl)c1)c1ccc(cc1)C(=O)NCc1nn[nH]n1 |r,wU:15.19,6.5,wD:12.13,c:10,(7.31,-14.38,;7.3,-12.84,;5.95,-12.09,;5.96,-13.59,;8.62,-12.05,;8.6,-10.51,;9.93,-9.73,;9.87,-8.19,;11.08,-7.24,;12.56,-7.66,;10.55,-5.79,;9.01,-5.85,;8.59,-7.33,;7.4,-6.35,;5.96,-6.88,;5.7,-8.4,;6.88,-9.38,;8.33,-8.85,;4.26,-8.93,;3.07,-7.94,;2.81,-9.46,;3.99,-10.45,;11.33,-4.46,;12.87,-4.48,;13.64,-3.15,;15.18,-3.15,;12.88,-1.8,;11.34,-1.8,;10.57,-.46,;10.56,-3.13,;11.25,-10.51,;11.23,-12.06,;12.55,-12.84,;13.9,-12.09,;13.92,-10.55,;12.6,-9.77,;15.22,-12.88,;15.2,-14.42,;16.56,-12.13,;17.89,-12.91,;19.23,-12.16,;20.63,-12.8,;21.67,-11.66,;20.91,-10.32,;19.4,-10.62,)| Show InChI InChI=1S/C34H43ClFN7O2/c1-32(2,3)14-13-27(21-7-9-22(10-8-21)30(44)37-20-28-39-41-42-40-28)43-31(45)29(23-17-25(35)19-26(36)18-23)38-34(43)15-11-24(12-16-34)33(4,5)6/h7-10,17-19,24,27H,11-16,20H2,1-6H3,(H,37,44)(H,39,40,41,42)/t24-,27-,34-/m1/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 42 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Antagonist activity at human GCGR expressed in CHO cells assessed as inhibition of glucagon-stimulated cAMP production preincubated for 30 mins follo... |
J Med Chem 57: 2601-10 (2014)
Article DOI: 10.1021/jm401858f
BindingDB Entry DOI: 10.7270/Q20V8F9P |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Mus musculus) | BDBM50007224
(CHEMBL3238216)Show SMILES CC(C)(C)CC[C@@H](N1C(=O)C(=N[C@@]11CC[C@@H](CC1)C(C)(C)C)c1cc(F)cc(Cl)c1)c1ccc(cc1)C(=O)NCc1nn[nH]n1 |r,wU:15.19,6.5,wD:12.13,c:10,(7.31,-14.38,;7.3,-12.84,;5.95,-12.09,;5.96,-13.59,;8.62,-12.05,;8.6,-10.51,;9.93,-9.73,;9.87,-8.19,;11.08,-7.24,;12.56,-7.66,;10.55,-5.79,;9.01,-5.85,;8.59,-7.33,;7.4,-6.35,;5.96,-6.88,;5.7,-8.4,;6.88,-9.38,;8.33,-8.85,;4.26,-8.93,;3.07,-7.94,;2.81,-9.46,;3.99,-10.45,;11.33,-4.46,;12.87,-4.48,;13.64,-3.15,;15.18,-3.15,;12.88,-1.8,;11.34,-1.8,;10.57,-.46,;10.56,-3.13,;11.25,-10.51,;11.23,-12.06,;12.55,-12.84,;13.9,-12.09,;13.92,-10.55,;12.6,-9.77,;15.22,-12.88,;15.2,-14.42,;16.56,-12.13,;17.89,-12.91,;19.23,-12.16,;20.63,-12.8,;21.67,-11.66,;20.91,-10.32,;19.4,-10.62,)| Show InChI InChI=1S/C34H43ClFN7O2/c1-32(2,3)14-13-27(21-7-9-22(10-8-21)30(44)37-20-28-39-41-42-40-28)43-31(45)29(23-17-25(35)19-26(36)18-23)38-34(43)15-11-24(12-16-34)33(4,5)6/h7-10,17-19,24,27H,11-16,20H2,1-6H3,(H,37,44)(H,39,40,41,42)/t24-,27-,34-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 160 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Displacement of [125I]-glucagon from GCGR in mouse liver membranes after 60 mins by scintillation counting analysis |
J Med Chem 57: 2601-10 (2014)
Article DOI: 10.1021/jm401858f
BindingDB Entry DOI: 10.7270/Q20V8F9P |
More data for this
Ligand-Target Pair | |
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