Found 3 hits Enz. Inhib. hit(s) with Target = 'Glucagon receptor' and Ligand = 'BDBM50007239' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Glucagon receptor
(Homo sapiens (Human)) | BDBM50007239
(CHEMBL3238226)Show SMILES CC(C)(C)CC[C@@H](N1C(=O)C(=N[C@@]11CC[C@@H](CC1)C(C)(C)C)c1cncc(Cl)c1)c1ccc(cc1)C(=O)NCc1nn[nH]n1 |r,wU:15.19,6.5,wD:12.13,c:10,(30.07,-58.93,;30.05,-57.39,;28.71,-56.63,;28.71,-58.14,;31.38,-56.6,;31.36,-55.06,;32.68,-54.28,;32.63,-52.74,;33.84,-51.79,;35.32,-52.2,;33.31,-50.34,;31.76,-50.4,;31.35,-51.88,;30.16,-50.89,;28.71,-51.43,;28.45,-52.94,;29.64,-53.93,;31.09,-53.4,;27.01,-53.48,;25.83,-52.49,;25.56,-54.01,;26.75,-54.99,;34.08,-49.01,;35.62,-49.02,;36.4,-47.69,;35.64,-46.35,;34.1,-46.35,;33.33,-45.01,;33.32,-47.68,;34.01,-55.06,;33.98,-56.61,;35.31,-57.39,;36.66,-56.64,;36.68,-55.1,;35.35,-54.32,;37.98,-57.43,;37.96,-58.97,;39.32,-56.68,;40.64,-57.46,;41.99,-56.71,;43.38,-57.34,;44.42,-56.21,;43.67,-54.87,;42.16,-55.17,)| Show InChI InChI=1S/C33H43ClN8O2/c1-31(2,3)14-13-26(21-7-9-22(10-8-21)29(43)36-20-27-38-40-41-39-27)42-30(44)28(23-17-25(34)19-35-18-23)37-33(42)15-11-24(12-16-33)32(4,5)6/h7-10,17-19,24,26H,11-16,20H2,1-6H3,(H,36,43)(H,38,39,40,41)/t24-,26-,33-/m1/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 38 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Displacement of [125I]-glucagon from recombinant human GCGR expressed in CHO cells after 60 mins by scintillation counting analysis |
J Med Chem 57: 2601-10 (2014)
Article DOI: 10.1021/jm401858f
BindingDB Entry DOI: 10.7270/Q20V8F9P |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Mus musculus) | BDBM50007239
(CHEMBL3238226)Show SMILES CC(C)(C)CC[C@@H](N1C(=O)C(=N[C@@]11CC[C@@H](CC1)C(C)(C)C)c1cncc(Cl)c1)c1ccc(cc1)C(=O)NCc1nn[nH]n1 |r,wU:15.19,6.5,wD:12.13,c:10,(30.07,-58.93,;30.05,-57.39,;28.71,-56.63,;28.71,-58.14,;31.38,-56.6,;31.36,-55.06,;32.68,-54.28,;32.63,-52.74,;33.84,-51.79,;35.32,-52.2,;33.31,-50.34,;31.76,-50.4,;31.35,-51.88,;30.16,-50.89,;28.71,-51.43,;28.45,-52.94,;29.64,-53.93,;31.09,-53.4,;27.01,-53.48,;25.83,-52.49,;25.56,-54.01,;26.75,-54.99,;34.08,-49.01,;35.62,-49.02,;36.4,-47.69,;35.64,-46.35,;34.1,-46.35,;33.33,-45.01,;33.32,-47.68,;34.01,-55.06,;33.98,-56.61,;35.31,-57.39,;36.66,-56.64,;36.68,-55.1,;35.35,-54.32,;37.98,-57.43,;37.96,-58.97,;39.32,-56.68,;40.64,-57.46,;41.99,-56.71,;43.38,-57.34,;44.42,-56.21,;43.67,-54.87,;42.16,-55.17,)| Show InChI InChI=1S/C33H43ClN8O2/c1-31(2,3)14-13-26(21-7-9-22(10-8-21)29(43)36-20-27-38-40-41-39-27)42-30(44)28(23-17-25(34)19-35-18-23)37-33(42)15-11-24(12-16-33)32(4,5)6/h7-10,17-19,24,26H,11-16,20H2,1-6H3,(H,36,43)(H,38,39,40,41)/t24-,26-,33-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 84 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Displacement of [125I]-glucagon from GCGR in mouse liver membranes after 60 mins by scintillation counting analysis |
J Med Chem 57: 2601-10 (2014)
Article DOI: 10.1021/jm401858f
BindingDB Entry DOI: 10.7270/Q20V8F9P |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM50007239
(CHEMBL3238226)Show SMILES CC(C)(C)CC[C@@H](N1C(=O)C(=N[C@@]11CC[C@@H](CC1)C(C)(C)C)c1cncc(Cl)c1)c1ccc(cc1)C(=O)NCc1nn[nH]n1 |r,wU:15.19,6.5,wD:12.13,c:10,(30.07,-58.93,;30.05,-57.39,;28.71,-56.63,;28.71,-58.14,;31.38,-56.6,;31.36,-55.06,;32.68,-54.28,;32.63,-52.74,;33.84,-51.79,;35.32,-52.2,;33.31,-50.34,;31.76,-50.4,;31.35,-51.88,;30.16,-50.89,;28.71,-51.43,;28.45,-52.94,;29.64,-53.93,;31.09,-53.4,;27.01,-53.48,;25.83,-52.49,;25.56,-54.01,;26.75,-54.99,;34.08,-49.01,;35.62,-49.02,;36.4,-47.69,;35.64,-46.35,;34.1,-46.35,;33.33,-45.01,;33.32,-47.68,;34.01,-55.06,;33.98,-56.61,;35.31,-57.39,;36.66,-56.64,;36.68,-55.1,;35.35,-54.32,;37.98,-57.43,;37.96,-58.97,;39.32,-56.68,;40.64,-57.46,;41.99,-56.71,;43.38,-57.34,;44.42,-56.21,;43.67,-54.87,;42.16,-55.17,)| Show InChI InChI=1S/C33H43ClN8O2/c1-31(2,3)14-13-26(21-7-9-22(10-8-21)29(43)36-20-27-38-40-41-39-27)42-30(44)28(23-17-25(34)19-35-18-23)37-33(42)15-11-24(12-16-33)32(4,5)6/h7-10,17-19,24,26H,11-16,20H2,1-6H3,(H,36,43)(H,38,39,40,41)/t24-,26-,33-/m1/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 480 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Antagonist activity at human GCGR expressed in CHO cells assessed as inhibition of glucagon-stimulated cAMP production preincubated for 30 mins follo... |
J Med Chem 57: 2601-10 (2014)
Article DOI: 10.1021/jm401858f
BindingDB Entry DOI: 10.7270/Q20V8F9P |
More data for this
Ligand-Target Pair | |
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