Found 3 hits Enz. Inhib. hit(s) with Target = 'Glucagon receptor' and Ligand = 'BDBM50007240' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Glucagon receptor
(Homo sapiens (Human)) | BDBM50007240
(CHEMBL3238228)Show SMILES CC(C)(C)CC[C@@H](N1C(=O)C(=N[C@@]11CC[C@@H](CC1)C(C)(C)C)c1cnccc1C(F)(F)F)c1ccc(cc1)C(=O)NCc1nn[nH]n1 |r,wU:15.19,6.5,wD:12.13,c:10,(5.79,-14.06,;5.77,-12.52,;4.43,-11.77,;4.43,-13.28,;7.1,-11.73,;7.08,-10.19,;8.4,-9.41,;8.35,-7.87,;9.56,-6.92,;11.04,-7.34,;9.03,-5.47,;7.48,-5.53,;7.07,-7.01,;5.88,-6.03,;4.43,-6.56,;4.17,-8.08,;5.36,-9.06,;6.8,-8.53,;2.73,-8.61,;1.55,-7.62,;1.28,-9.14,;2.47,-10.13,;9.8,-4.14,;11.34,-4.16,;12.12,-2.83,;11.36,-1.48,;9.82,-1.48,;9.04,-2.81,;7.5,-2.8,;6.74,-1.47,;6.72,-4.13,;5.96,-2.79,;9.73,-10.19,;9.7,-11.74,;11.03,-12.52,;12.38,-11.77,;12.4,-10.23,;11.07,-9.45,;13.7,-12.56,;13.68,-14.1,;15.04,-11.81,;16.36,-12.59,;17.71,-11.84,;19.1,-12.48,;20.15,-11.34,;19.39,-10,;17.88,-10.31,)| Show InChI InChI=1S/C34H43F3N8O2/c1-31(2,3)15-13-26(21-7-9-22(10-8-21)29(46)39-20-27-41-43-44-42-27)45-30(47)28(24-19-38-18-14-25(24)34(35,36)37)40-33(45)16-11-23(12-17-33)32(4,5)6/h7-10,14,18-19,23,26H,11-13,15-17,20H2,1-6H3,(H,39,46)(H,41,42,43,44)/t23-,26-,33-/m1/s1 | PDB MMDB
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Displacement of [125I]-glucagon from recombinant human GCGR expressed in CHO cells after 60 mins by scintillation counting analysis |
J Med Chem 57: 2601-10 (2014)
Article DOI: 10.1021/jm401858f BindingDB Entry DOI: 10.7270/Q20V8F9P |
More data for this Ligand-Target Pair | |
Glucagon receptor
(Mus musculus) | BDBM50007240
(CHEMBL3238228)Show SMILES CC(C)(C)CC[C@@H](N1C(=O)C(=N[C@@]11CC[C@@H](CC1)C(C)(C)C)c1cnccc1C(F)(F)F)c1ccc(cc1)C(=O)NCc1nn[nH]n1 |r,wU:15.19,6.5,wD:12.13,c:10,(5.79,-14.06,;5.77,-12.52,;4.43,-11.77,;4.43,-13.28,;7.1,-11.73,;7.08,-10.19,;8.4,-9.41,;8.35,-7.87,;9.56,-6.92,;11.04,-7.34,;9.03,-5.47,;7.48,-5.53,;7.07,-7.01,;5.88,-6.03,;4.43,-6.56,;4.17,-8.08,;5.36,-9.06,;6.8,-8.53,;2.73,-8.61,;1.55,-7.62,;1.28,-9.14,;2.47,-10.13,;9.8,-4.14,;11.34,-4.16,;12.12,-2.83,;11.36,-1.48,;9.82,-1.48,;9.04,-2.81,;7.5,-2.8,;6.74,-1.47,;6.72,-4.13,;5.96,-2.79,;9.73,-10.19,;9.7,-11.74,;11.03,-12.52,;12.38,-11.77,;12.4,-10.23,;11.07,-9.45,;13.7,-12.56,;13.68,-14.1,;15.04,-11.81,;16.36,-12.59,;17.71,-11.84,;19.1,-12.48,;20.15,-11.34,;19.39,-10,;17.88,-10.31,)| Show InChI InChI=1S/C34H43F3N8O2/c1-31(2,3)15-13-26(21-7-9-22(10-8-21)29(46)39-20-27-41-43-44-42-27)45-30(47)28(24-19-38-18-14-25(24)34(35,36)37)40-33(45)16-11-23(12-17-33)32(4,5)6/h7-10,14,18-19,23,26H,11-13,15-17,20H2,1-6H3,(H,39,46)(H,41,42,43,44)/t23-,26-,33-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 96 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Displacement of [125I]-glucagon from GCGR in mouse liver membranes after 60 mins by scintillation counting analysis |
J Med Chem 57: 2601-10 (2014)
Article DOI: 10.1021/jm401858f BindingDB Entry DOI: 10.7270/Q20V8F9P |
More data for this Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM50007240
(CHEMBL3238228)Show SMILES CC(C)(C)CC[C@@H](N1C(=O)C(=N[C@@]11CC[C@@H](CC1)C(C)(C)C)c1cnccc1C(F)(F)F)c1ccc(cc1)C(=O)NCc1nn[nH]n1 |r,wU:15.19,6.5,wD:12.13,c:10,(5.79,-14.06,;5.77,-12.52,;4.43,-11.77,;4.43,-13.28,;7.1,-11.73,;7.08,-10.19,;8.4,-9.41,;8.35,-7.87,;9.56,-6.92,;11.04,-7.34,;9.03,-5.47,;7.48,-5.53,;7.07,-7.01,;5.88,-6.03,;4.43,-6.56,;4.17,-8.08,;5.36,-9.06,;6.8,-8.53,;2.73,-8.61,;1.55,-7.62,;1.28,-9.14,;2.47,-10.13,;9.8,-4.14,;11.34,-4.16,;12.12,-2.83,;11.36,-1.48,;9.82,-1.48,;9.04,-2.81,;7.5,-2.8,;6.74,-1.47,;6.72,-4.13,;5.96,-2.79,;9.73,-10.19,;9.7,-11.74,;11.03,-12.52,;12.38,-11.77,;12.4,-10.23,;11.07,-9.45,;13.7,-12.56,;13.68,-14.1,;15.04,-11.81,;16.36,-12.59,;17.71,-11.84,;19.1,-12.48,;20.15,-11.34,;19.39,-10,;17.88,-10.31,)| Show InChI InChI=1S/C34H43F3N8O2/c1-31(2,3)15-13-26(21-7-9-22(10-8-21)29(46)39-20-27-41-43-44-42-27)45-30(47)28(24-19-38-18-14-25(24)34(35,36)37)40-33(45)16-11-23(12-17-33)32(4,5)6/h7-10,14,18-19,23,26H,11-13,15-17,20H2,1-6H3,(H,39,46)(H,41,42,43,44)/t23-,26-,33-/m1/s1 | PDB MMDB
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Antagonist activity at human GCGR expressed in CHO cells assessed as inhibition of glucagon-stimulated cAMP production preincubated for 30 mins follo... |
J Med Chem 57: 2601-10 (2014)
Article DOI: 10.1021/jm401858f BindingDB Entry DOI: 10.7270/Q20V8F9P |
More data for this Ligand-Target Pair | |