Found 3 hits Enz. Inhib. hit(s) with Target = 'Glucagon receptor' and Ligand = 'BDBM50007417' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Glucagon receptor
(Homo sapiens (Human)) | BDBM50007417
(CHEMBL3237905)Show SMILES C[C@@H](N1C(=O)C(=N[C@@]11CC[C@@H](CC1)C(C)(C)C)c1ccc(F)c(Cl)c1)c1ccc(cc1)C(=O)NCCC(O)=O |r,wU:10.14,1.0,wD:7.8,c:5,(59.7,-43.26,;61.02,-42.48,;60.97,-40.94,;62.18,-39.99,;63.65,-40.41,;61.65,-38.54,;60.1,-38.61,;59.69,-40.08,;58.5,-39.1,;57.05,-39.63,;56.79,-41.15,;57.98,-42.13,;59.42,-41.6,;55.35,-41.68,;54.17,-40.69,;53.9,-42.21,;55.09,-43.2,;62.42,-37.21,;63.96,-37.23,;64.74,-35.9,;63.98,-34.56,;64.76,-33.23,;62.43,-34.55,;61.67,-33.21,;61.66,-35.88,;62.34,-43.26,;62.32,-44.81,;63.65,-45.59,;64.99,-44.84,;65.01,-43.3,;63.69,-42.52,;66.32,-45.63,;66.3,-47.17,;67.66,-44.88,;68.98,-45.66,;70.32,-44.91,;71.65,-45.69,;72.99,-44.94,;71.63,-47.23,)| Show InChI InChI=1S/C30H35ClFN3O4/c1-18(19-5-7-20(8-6-19)27(38)33-16-13-25(36)37)35-28(39)26(21-9-10-24(32)23(31)17-21)34-30(35)14-11-22(12-15-30)29(2,3)4/h5-10,17-18,22H,11-16H2,1-4H3,(H,33,38)(H,36,37)/t18-,22-,30-/m1/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 44 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Displacement of [125I]-glucagon from recombinant human GCGR expressed in CHO cells after 60 mins by scintillation counting analysis |
J Med Chem 57: 2601-10 (2014)
Article DOI: 10.1021/jm401858f
BindingDB Entry DOI: 10.7270/Q20V8F9P |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM50007417
(CHEMBL3237905)Show SMILES C[C@@H](N1C(=O)C(=N[C@@]11CC[C@@H](CC1)C(C)(C)C)c1ccc(F)c(Cl)c1)c1ccc(cc1)C(=O)NCCC(O)=O |r,wU:10.14,1.0,wD:7.8,c:5,(59.7,-43.26,;61.02,-42.48,;60.97,-40.94,;62.18,-39.99,;63.65,-40.41,;61.65,-38.54,;60.1,-38.61,;59.69,-40.08,;58.5,-39.1,;57.05,-39.63,;56.79,-41.15,;57.98,-42.13,;59.42,-41.6,;55.35,-41.68,;54.17,-40.69,;53.9,-42.21,;55.09,-43.2,;62.42,-37.21,;63.96,-37.23,;64.74,-35.9,;63.98,-34.56,;64.76,-33.23,;62.43,-34.55,;61.67,-33.21,;61.66,-35.88,;62.34,-43.26,;62.32,-44.81,;63.65,-45.59,;64.99,-44.84,;65.01,-43.3,;63.69,-42.52,;66.32,-45.63,;66.3,-47.17,;67.66,-44.88,;68.98,-45.66,;70.32,-44.91,;71.65,-45.69,;72.99,-44.94,;71.63,-47.23,)| Show InChI InChI=1S/C30H35ClFN3O4/c1-18(19-5-7-20(8-6-19)27(38)33-16-13-25(36)37)35-28(39)26(21-9-10-24(32)23(31)17-21)34-30(35)14-11-22(12-15-30)29(2,3)4/h5-10,17-18,22H,11-16H2,1-4H3,(H,33,38)(H,36,37)/t18-,22-,30-/m1/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 440 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Antagonist activity at human GCGR expressed in CHO cells assessed as inhibition of glucagon-stimulated cAMP production preincubated for 30 mins follo... |
J Med Chem 57: 2601-10 (2014)
Article DOI: 10.1021/jm401858f
BindingDB Entry DOI: 10.7270/Q20V8F9P |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Mus musculus) | BDBM50007417
(CHEMBL3237905)Show SMILES C[C@@H](N1C(=O)C(=N[C@@]11CC[C@@H](CC1)C(C)(C)C)c1ccc(F)c(Cl)c1)c1ccc(cc1)C(=O)NCCC(O)=O |r,wU:10.14,1.0,wD:7.8,c:5,(59.7,-43.26,;61.02,-42.48,;60.97,-40.94,;62.18,-39.99,;63.65,-40.41,;61.65,-38.54,;60.1,-38.61,;59.69,-40.08,;58.5,-39.1,;57.05,-39.63,;56.79,-41.15,;57.98,-42.13,;59.42,-41.6,;55.35,-41.68,;54.17,-40.69,;53.9,-42.21,;55.09,-43.2,;62.42,-37.21,;63.96,-37.23,;64.74,-35.9,;63.98,-34.56,;64.76,-33.23,;62.43,-34.55,;61.67,-33.21,;61.66,-35.88,;62.34,-43.26,;62.32,-44.81,;63.65,-45.59,;64.99,-44.84,;65.01,-43.3,;63.69,-42.52,;66.32,-45.63,;66.3,-47.17,;67.66,-44.88,;68.98,-45.66,;70.32,-44.91,;71.65,-45.69,;72.99,-44.94,;71.63,-47.23,)| Show InChI InChI=1S/C30H35ClFN3O4/c1-18(19-5-7-20(8-6-19)27(38)33-16-13-25(36)37)35-28(39)26(21-9-10-24(32)23(31)17-21)34-30(35)14-11-22(12-15-30)29(2,3)4/h5-10,17-18,22H,11-16H2,1-4H3,(H,33,38)(H,36,37)/t18-,22-,30-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Displacement of [125I]-glucagon from GCGR in mouse liver membranes after 60 mins by scintillation counting analysis |
J Med Chem 57: 2601-10 (2014)
Article DOI: 10.1021/jm401858f
BindingDB Entry DOI: 10.7270/Q20V8F9P |
More data for this
Ligand-Target Pair | |
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