Found 4 hits Enz. Inhib. hit(s) with Target = 'Glucagon receptor' and Ligand = 'BDBM50199498' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Glucagon receptor
(Homo sapiens (Human)) | BDBM50199498
(3-(1-(1-((1r,4r)-4-tert-butylcyclohexyl)-3-(4-(tri...)Show SMILES CC(C)(C)[C@H]1CC[C@@H](CC1)N(C1CCc2cc(ccc12)C(=O)NCCC(O)=O)C(=O)Nc1ccc(OC(F)(F)F)cc1 |w:11.11,wU:7.10,wD:4.3,(-2.01,-7.56,;-2,-6.03,;-.46,-6.04,;-3.54,-6.03,;-2,-4.49,;-.66,-3.72,;-.65,-2.17,;-1.98,-1.41,;-3.33,-2.18,;-3.33,-3.71,;-1.98,.13,;-.64,.9,;-.33,2.4,;1.53,2.36,;2.01,.91,;3.34,.15,;3.35,-1.4,;2.01,-2.17,;.68,-1.41,;.69,.13,;4.68,-2.17,;4.69,-3.71,;6.02,-1.4,;7.35,-2.16,;8.68,-1.39,;10.02,-2.16,;11.35,-1.39,;10.02,-3.7,;-3.31,.9,;-3.32,2.44,;-4.65,.13,;-5.98,.89,;-7.32,.12,;-8.65,.89,;-8.65,2.44,;-9.99,3.21,;-9.99,4.75,;-10,6.29,;-8.45,4.75,;-11.53,4.74,;-7.33,3.21,;-5.99,2.45,)| Show InChI InChI=1S/C31H38F3N3O5/c1-30(2,3)21-6-10-23(11-7-21)37(29(41)36-22-8-12-24(13-9-22)42-31(32,33)34)26-15-5-19-18-20(4-14-25(19)26)28(40)35-17-16-27(38)39/h4,8-9,12-14,18,21,23,26H,5-7,10-11,15-17H2,1-3H3,(H,35,40)(H,36,41)(H,38,39)/t21-,23-,26? | PDB MMDB
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 4.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Displacement of [125]glucagon from human glucagon receptor expressed in CHO cells |
Bioorg Med Chem Lett 17: 587-92 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.014 BindingDB Entry DOI: 10.7270/Q2N58M0Q |
More data for this Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM50199498
(3-(1-(1-((1r,4r)-4-tert-butylcyclohexyl)-3-(4-(tri...)Show SMILES CC(C)(C)[C@H]1CC[C@@H](CC1)N(C1CCc2cc(ccc12)C(=O)NCCC(O)=O)C(=O)Nc1ccc(OC(F)(F)F)cc1 |w:11.11,wU:7.10,wD:4.3,(-2.01,-7.56,;-2,-6.03,;-.46,-6.04,;-3.54,-6.03,;-2,-4.49,;-.66,-3.72,;-.65,-2.17,;-1.98,-1.41,;-3.33,-2.18,;-3.33,-3.71,;-1.98,.13,;-.64,.9,;-.33,2.4,;1.53,2.36,;2.01,.91,;3.34,.15,;3.35,-1.4,;2.01,-2.17,;.68,-1.41,;.69,.13,;4.68,-2.17,;4.69,-3.71,;6.02,-1.4,;7.35,-2.16,;8.68,-1.39,;10.02,-2.16,;11.35,-1.39,;10.02,-3.7,;-3.31,.9,;-3.32,2.44,;-4.65,.13,;-5.98,.89,;-7.32,.12,;-8.65,.89,;-8.65,2.44,;-9.99,3.21,;-9.99,4.75,;-10,6.29,;-8.45,4.75,;-11.53,4.74,;-7.33,3.21,;-5.99,2.45,)| Show InChI InChI=1S/C31H38F3N3O5/c1-30(2,3)21-6-10-23(11-7-21)37(29(41)36-22-8-12-24(13-9-22)42-31(32,33)34)26-15-5-19-18-20(4-14-25(19)26)28(40)35-17-16-27(38)39/h4,8-9,12-14,18,21,23,26H,5-7,10-11,15-17H2,1-3H3,(H,35,40)(H,36,41)(H,38,39)/t21-,23-,26? | PDB MMDB
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 4.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Displacement of [125]glucagon from human glucagon receptor expressed in CHO cells |
Bioorg Med Chem Lett 17: 587-92 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.014 BindingDB Entry DOI: 10.7270/Q2N58M0Q |
More data for this Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM50199498
(3-(1-(1-((1r,4r)-4-tert-butylcyclohexyl)-3-(4-(tri...)Show SMILES CC(C)(C)[C@H]1CC[C@@H](CC1)N(C1CCc2cc(ccc12)C(=O)NCCC(O)=O)C(=O)Nc1ccc(OC(F)(F)F)cc1 |w:11.11,wU:7.10,wD:4.3,(-2.01,-7.56,;-2,-6.03,;-.46,-6.04,;-3.54,-6.03,;-2,-4.49,;-.66,-3.72,;-.65,-2.17,;-1.98,-1.41,;-3.33,-2.18,;-3.33,-3.71,;-1.98,.13,;-.64,.9,;-.33,2.4,;1.53,2.36,;2.01,.91,;3.34,.15,;3.35,-1.4,;2.01,-2.17,;.68,-1.41,;.69,.13,;4.68,-2.17,;4.69,-3.71,;6.02,-1.4,;7.35,-2.16,;8.68,-1.39,;10.02,-2.16,;11.35,-1.39,;10.02,-3.7,;-3.31,.9,;-3.32,2.44,;-4.65,.13,;-5.98,.89,;-7.32,.12,;-8.65,.89,;-8.65,2.44,;-9.99,3.21,;-9.99,4.75,;-10,6.29,;-8.45,4.75,;-11.53,4.74,;-7.33,3.21,;-5.99,2.45,)| Show InChI InChI=1S/C31H38F3N3O5/c1-30(2,3)21-6-10-23(11-7-21)37(29(41)36-22-8-12-24(13-9-22)42-31(32,33)34)26-15-5-19-18-20(4-14-25(19)26)28(40)35-17-16-27(38)39/h4,8-9,12-14,18,21,23,26H,5-7,10-11,15-17H2,1-3H3,(H,35,40)(H,36,41)(H,38,39)/t21-,23-,26? | PDB MMDB
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 33 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Antagonist activity at human glucagon receptor transfected in CHO cells assessed as inhibition of glucagon-induced cAMP accumulation |
Bioorg Med Chem Lett 17: 587-92 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.014 BindingDB Entry DOI: 10.7270/Q2N58M0Q |
More data for this Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM50199498
(3-(1-(1-((1r,4r)-4-tert-butylcyclohexyl)-3-(4-(tri...)Show SMILES CC(C)(C)[C@H]1CC[C@@H](CC1)N(C1CCc2cc(ccc12)C(=O)NCCC(O)=O)C(=O)Nc1ccc(OC(F)(F)F)cc1 |w:11.11,wU:7.10,wD:4.3,(-2.01,-7.56,;-2,-6.03,;-.46,-6.04,;-3.54,-6.03,;-2,-4.49,;-.66,-3.72,;-.65,-2.17,;-1.98,-1.41,;-3.33,-2.18,;-3.33,-3.71,;-1.98,.13,;-.64,.9,;-.33,2.4,;1.53,2.36,;2.01,.91,;3.34,.15,;3.35,-1.4,;2.01,-2.17,;.68,-1.41,;.69,.13,;4.68,-2.17,;4.69,-3.71,;6.02,-1.4,;7.35,-2.16,;8.68,-1.39,;10.02,-2.16,;11.35,-1.39,;10.02,-3.7,;-3.31,.9,;-3.32,2.44,;-4.65,.13,;-5.98,.89,;-7.32,.12,;-8.65,.89,;-8.65,2.44,;-9.99,3.21,;-9.99,4.75,;-10,6.29,;-8.45,4.75,;-11.53,4.74,;-7.33,3.21,;-5.99,2.45,)| Show InChI InChI=1S/C31H38F3N3O5/c1-30(2,3)21-6-10-23(11-7-21)37(29(41)36-22-8-12-24(13-9-22)42-31(32,33)34)26-15-5-19-18-20(4-14-25(19)26)28(40)35-17-16-27(38)39/h4,8-9,12-14,18,21,23,26H,5-7,10-11,15-17H2,1-3H3,(H,35,40)(H,36,41)(H,38,39)/t21-,23-,26? | PDB MMDB
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 33 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Antagonist activity at human glucagon receptor transfected in CHO cells assessed as inhibition of glucagon-induced cAMP accumulation |
Bioorg Med Chem Lett 17: 587-92 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.014 BindingDB Entry DOI: 10.7270/Q2N58M0Q |
More data for this Ligand-Target Pair | |