Found 3 hits Enz. Inhib. hit(s) with Target = 'Glucagon-like peptide 1 receptor' and Ligand = 'BDBM50231881' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50231881
(CHEMBL4063807)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@@H]1CCC(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(N)=O |r| Show InChI InChI=1S/C154H231N41O47/c1-17-78(10)123(151(240)171-82(14)129(218)181-106(62-88-65-163-92-36-25-24-35-91(88)92)141(230)183-102(58-75(4)5)142(231)191-121(76(6)7)149(238)180-94(37-26-28-54-155)131(220)165-68-115(205)172-93(39-30-56-162-154(159)160)130(219)164-67-113(158)203)193-143(232)104(59-85-31-20-18-21-32-85)184-136(225)100(48-53-119(211)212)179-134(223)95(38-27-29-55-156)175-127(216)80(12)168-126(215)79(11)169-133(222)97(44-49-112(157)202)173-116(206)69-166-132(221)96(46-51-117(207)208)177-139(228)101(57-74(2)3)182-140(229)103(61-87-40-42-90(201)43-41-87)185-146(235)109(70-196)188-148(237)111(72-198)189-150(239)122(77(8)9)192-145(234)108(64-120(213)214)186-147(236)110(71-197)190-153(242)125(84(16)200)195-144(233)105(60-86-33-22-19-23-34-86)187-152(241)124(83(15)199)194-137(226)98-45-50-114(204)174-107(63-89-66-161-73-167-89)138(227)170-81(13)128(217)176-99(135(224)178-98)47-52-118(209)210/h18-25,31-36,40-43,65-66,73-84,93-111,121-125,163,196-201H,17,26-30,37-39,44-64,67-72,155-156H2,1-16H3,(H2,157,202)(H2,158,203)(H,161,167)(H,164,219)(H,165,220)(H,166,221)(H,168,215)(H,169,222)(H,170,227)(H,171,240)(H,172,205)(H,173,206)(H,174,204)(H,175,216)(H,176,217)(H,177,228)(H,178,224)(H,179,223)(H,180,238)(H,181,218)(H,182,229)(H,183,230)(H,184,225)(H,185,235)(H,186,236)(H,187,241)(H,188,237)(H,189,239)(H,190,242)(H,191,231)(H,192,234)(H,193,232)(H,194,226)(H,195,233)(H,207,208)(H,209,210)(H,211,212)(H,213,214)(H4,159,160,162)/t78-,79-,80-,81-,82-,83+,84+,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,121-,122-,123-,124-,125-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| 34 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Queensland
Curated by ChEMBL
| Assay Description
Displacement of [125I]-GLP (7 to 36 residues) from human GLP1R expressed in CHO cell membranes incubated for 30 mins measured after 10 hrs by scintil... |
Eur J Med Chem 127: 703-714 (2017)
Article DOI: 10.1016/j.ejmech.2016.10.044
BindingDB Entry DOI: 10.7270/Q2T155W1 |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50231881
(CHEMBL4063807)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@@H]1CCC(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(N)=O |r| Show InChI InChI=1S/C154H231N41O47/c1-17-78(10)123(151(240)171-82(14)129(218)181-106(62-88-65-163-92-36-25-24-35-91(88)92)141(230)183-102(58-75(4)5)142(231)191-121(76(6)7)149(238)180-94(37-26-28-54-155)131(220)165-68-115(205)172-93(39-30-56-162-154(159)160)130(219)164-67-113(158)203)193-143(232)104(59-85-31-20-18-21-32-85)184-136(225)100(48-53-119(211)212)179-134(223)95(38-27-29-55-156)175-127(216)80(12)168-126(215)79(11)169-133(222)97(44-49-112(157)202)173-116(206)69-166-132(221)96(46-51-117(207)208)177-139(228)101(57-74(2)3)182-140(229)103(61-87-40-42-90(201)43-41-87)185-146(235)109(70-196)188-148(237)111(72-198)189-150(239)122(77(8)9)192-145(234)108(64-120(213)214)186-147(236)110(71-197)190-153(242)125(84(16)200)195-144(233)105(60-86-33-22-19-23-34-86)187-152(241)124(83(15)199)194-137(226)98-45-50-114(204)174-107(63-89-66-161-73-167-89)138(227)170-81(13)128(217)176-99(135(224)178-98)47-52-118(209)210/h18-25,31-36,40-43,65-66,73-84,93-111,121-125,163,196-201H,17,26-30,37-39,44-64,67-72,155-156H2,1-16H3,(H2,157,202)(H2,158,203)(H,161,167)(H,164,219)(H,165,220)(H,166,221)(H,168,215)(H,169,222)(H,170,227)(H,171,240)(H,172,205)(H,173,206)(H,174,204)(H,175,216)(H,176,217)(H,177,228)(H,178,224)(H,179,223)(H,180,238)(H,181,218)(H,182,229)(H,183,230)(H,184,225)(H,185,235)(H,186,236)(H,187,241)(H,188,237)(H,189,239)(H,190,242)(H,191,231)(H,192,234)(H,193,232)(H,194,226)(H,195,233)(H,207,208)(H,209,210)(H,211,212)(H,213,214)(H4,159,160,162)/t78-,79-,80-,81-,82-,83+,84+,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,121-,122-,123-,124-,125-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a |
The University of Queensland
Curated by ChEMBL
| Assay Description
Agonist activity at human GLP1R expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by LANCE assay |
Eur J Med Chem 127: 703-714 (2017)
Article DOI: 10.1016/j.ejmech.2016.10.044
BindingDB Entry DOI: 10.7270/Q2T155W1 |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50231881
(CHEMBL4063807)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@@H]1CCC(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(N)=O |r| Show InChI InChI=1S/C154H231N41O47/c1-17-78(10)123(151(240)171-82(14)129(218)181-106(62-88-65-163-92-36-25-24-35-91(88)92)141(230)183-102(58-75(4)5)142(231)191-121(76(6)7)149(238)180-94(37-26-28-54-155)131(220)165-68-115(205)172-93(39-30-56-162-154(159)160)130(219)164-67-113(158)203)193-143(232)104(59-85-31-20-18-21-32-85)184-136(225)100(48-53-119(211)212)179-134(223)95(38-27-29-55-156)175-127(216)80(12)168-126(215)79(11)169-133(222)97(44-49-112(157)202)173-116(206)69-166-132(221)96(46-51-117(207)208)177-139(228)101(57-74(2)3)182-140(229)103(61-87-40-42-90(201)43-41-87)185-146(235)109(70-196)188-148(237)111(72-198)189-150(239)122(77(8)9)192-145(234)108(64-120(213)214)186-147(236)110(71-197)190-153(242)125(84(16)200)195-144(233)105(60-86-33-22-19-23-34-86)187-152(241)124(83(15)199)194-137(226)98-45-50-114(204)174-107(63-89-66-161-73-167-89)138(227)170-81(13)128(217)176-99(135(224)178-98)47-52-118(209)210/h18-25,31-36,40-43,65-66,73-84,93-111,121-125,163,196-201H,17,26-30,37-39,44-64,67-72,155-156H2,1-16H3,(H2,157,202)(H2,158,203)(H,161,167)(H,164,219)(H,165,220)(H,166,221)(H,168,215)(H,169,222)(H,170,227)(H,171,240)(H,172,205)(H,173,206)(H,174,204)(H,175,216)(H,176,217)(H,177,228)(H,178,224)(H,179,223)(H,180,238)(H,181,218)(H,182,229)(H,183,230)(H,184,225)(H,185,235)(H,186,236)(H,187,241)(H,188,237)(H,189,239)(H,190,242)(H,191,231)(H,192,234)(H,193,232)(H,194,226)(H,195,233)(H,207,208)(H,209,210)(H,211,212)(H,213,214)(H4,159,160,162)/t78-,79-,80-,81-,82-,83+,84+,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,121-,122-,123-,124-,125-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a |
The University of Queensland
Curated by ChEMBL
| Assay Description
Agonist activity at human GLP1R expressed in CHOK1 cells assessed as induction of beta-galactosidase-tagged beta-arrestin2 recruitment incubated for ... |
Eur J Med Chem 127: 703-714 (2017)
Article DOI: 10.1016/j.ejmech.2016.10.044
BindingDB Entry DOI: 10.7270/Q2T155W1 |
More data for this
Ligand-Target Pair | |
Search and Browse
