Found 3 hits Enz. Inhib. hit(s) with Target = 'Glucagon-like peptide 1 receptor' and Ligand = 'BDBM50231898' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50231898
(CHEMBL4079909)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(C)C)C(=O)N[C@H]1CCCCNC(=O)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O)C(C)C)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(N)=O |r| Show InChI InChI=1S/C155H233N41O47/c1-18-79(12)124(152(241)178-96-39-28-30-54-163-114(205)63-107(133(222)168-68-115(206)173-94(40-31-55-164-155(160)161)131(220)166-67-113(159)204)187-150(239)122(77(8)9)193-142(231)102(57-75(4)5)181-141(230)106(184-136(96)225)61-88-65-165-93-37-26-25-36-91(88)93)195-143(232)104(58-85-32-21-19-22-33-85)182-137(226)99(47-51-118(210)211)176-135(224)95(38-27-29-53-156)174-128(217)81(14)170-127(216)80(13)172-134(223)98(45-49-112(158)203)179-149(238)121(76(6)7)192-138(227)100(48-52-119(212)213)177-139(228)101(56-74(2)3)180-140(229)103(60-87-41-43-90(202)44-42-87)183-146(235)109(70-197)188-148(237)111(72-199)189-151(240)123(78(10)11)194-145(234)108(64-120(214)215)185-147(236)110(71-198)190-154(243)126(84(17)201)196-144(233)105(59-86-34-23-20-24-35-86)186-153(242)125(83(16)200)191-116(207)69-167-132(221)97(46-50-117(208)209)175-129(218)82(15)171-130(219)92(157)62-89-66-162-73-169-89/h19-26,32-37,41-44,65-66,73-84,92,94-111,121-126,165,197-202H,18,27-31,38-40,45-64,67-72,156-157H2,1-17H3,(H2,158,203)(H2,159,204)(H,162,169)(H,163,205)(H,166,220)(H,167,221)(H,168,222)(H,170,216)(H,171,219)(H,172,223)(H,173,206)(H,174,217)(H,175,218)(H,176,224)(H,177,228)(H,178,241)(H,179,238)(H,180,229)(H,181,230)(H,182,226)(H,183,235)(H,184,225)(H,185,236)(H,186,242)(H,187,239)(H,188,237)(H,189,240)(H,190,243)(H,191,207)(H,192,227)(H,193,231)(H,194,234)(H,195,232)(H,196,233)(H,208,209)(H,210,211)(H,212,213)(H,214,215)(H4,160,161,164)/t79-,80-,81-,82-,83+,84+,92-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,121-,122-,123-,124-,125-,126-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Queensland
Curated by ChEMBL
| Assay Description
Displacement of [125I]-GLP (7 to 36 residues) from human GLP1R expressed in CHO cell membranes incubated for 30 mins measured after 10 hrs by scintil... |
Eur J Med Chem 127: 703-714 (2017)
Article DOI: 10.1016/j.ejmech.2016.10.044
BindingDB Entry DOI: 10.7270/Q2T155W1 |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50231898
(CHEMBL4079909)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(C)C)C(=O)N[C@H]1CCCCNC(=O)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O)C(C)C)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(N)=O |r| Show InChI InChI=1S/C155H233N41O47/c1-18-79(12)124(152(241)178-96-39-28-30-54-163-114(205)63-107(133(222)168-68-115(206)173-94(40-31-55-164-155(160)161)131(220)166-67-113(159)204)187-150(239)122(77(8)9)193-142(231)102(57-75(4)5)181-141(230)106(184-136(96)225)61-88-65-165-93-37-26-25-36-91(88)93)195-143(232)104(58-85-32-21-19-22-33-85)182-137(226)99(47-51-118(210)211)176-135(224)95(38-27-29-53-156)174-128(217)81(14)170-127(216)80(13)172-134(223)98(45-49-112(158)203)179-149(238)121(76(6)7)192-138(227)100(48-52-119(212)213)177-139(228)101(56-74(2)3)180-140(229)103(60-87-41-43-90(202)44-42-87)183-146(235)109(70-197)188-148(237)111(72-199)189-151(240)123(78(10)11)194-145(234)108(64-120(214)215)185-147(236)110(71-198)190-154(243)126(84(17)201)196-144(233)105(59-86-34-23-20-24-35-86)186-153(242)125(83(16)200)191-116(207)69-167-132(221)97(46-50-117(208)209)175-129(218)82(15)171-130(219)92(157)62-89-66-162-73-169-89/h19-26,32-37,41-44,65-66,73-84,92,94-111,121-126,165,197-202H,18,27-31,38-40,45-64,67-72,156-157H2,1-17H3,(H2,158,203)(H2,159,204)(H,162,169)(H,163,205)(H,166,220)(H,167,221)(H,168,222)(H,170,216)(H,171,219)(H,172,223)(H,173,206)(H,174,217)(H,175,218)(H,176,224)(H,177,228)(H,178,241)(H,179,238)(H,180,229)(H,181,230)(H,182,226)(H,183,235)(H,184,225)(H,185,236)(H,186,242)(H,187,239)(H,188,237)(H,189,240)(H,190,243)(H,191,207)(H,192,227)(H,193,231)(H,194,234)(H,195,232)(H,196,233)(H,208,209)(H,210,211)(H,212,213)(H,214,215)(H4,160,161,164)/t79-,80-,81-,82-,83+,84+,92-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,121-,122-,123-,124-,125-,126-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.100 | n/a | n/a | n/a | n/a |
The University of Queensland
Curated by ChEMBL
| Assay Description
Agonist activity at human GLP1R expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by LANCE assay |
Eur J Med Chem 127: 703-714 (2017)
Article DOI: 10.1016/j.ejmech.2016.10.044
BindingDB Entry DOI: 10.7270/Q2T155W1 |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50231898
(CHEMBL4079909)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(C)C)C(=O)N[C@H]1CCCCNC(=O)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O)C(C)C)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(N)=O |r| Show InChI InChI=1S/C155H233N41O47/c1-18-79(12)124(152(241)178-96-39-28-30-54-163-114(205)63-107(133(222)168-68-115(206)173-94(40-31-55-164-155(160)161)131(220)166-67-113(159)204)187-150(239)122(77(8)9)193-142(231)102(57-75(4)5)181-141(230)106(184-136(96)225)61-88-65-165-93-37-26-25-36-91(88)93)195-143(232)104(58-85-32-21-19-22-33-85)182-137(226)99(47-51-118(210)211)176-135(224)95(38-27-29-53-156)174-128(217)81(14)170-127(216)80(13)172-134(223)98(45-49-112(158)203)179-149(238)121(76(6)7)192-138(227)100(48-52-119(212)213)177-139(228)101(56-74(2)3)180-140(229)103(60-87-41-43-90(202)44-42-87)183-146(235)109(70-197)188-148(237)111(72-199)189-151(240)123(78(10)11)194-145(234)108(64-120(214)215)185-147(236)110(71-198)190-154(243)126(84(17)201)196-144(233)105(59-86-34-23-20-24-35-86)186-153(242)125(83(16)200)191-116(207)69-167-132(221)97(46-50-117(208)209)175-129(218)82(15)171-130(219)92(157)62-89-66-162-73-169-89/h19-26,32-37,41-44,65-66,73-84,92,94-111,121-126,165,197-202H,18,27-31,38-40,45-64,67-72,156-157H2,1-17H3,(H2,158,203)(H2,159,204)(H,162,169)(H,163,205)(H,166,220)(H,167,221)(H,168,222)(H,170,216)(H,171,219)(H,172,223)(H,173,206)(H,174,217)(H,175,218)(H,176,224)(H,177,228)(H,178,241)(H,179,238)(H,180,229)(H,181,230)(H,182,226)(H,183,235)(H,184,225)(H,185,236)(H,186,242)(H,187,239)(H,188,237)(H,189,240)(H,190,243)(H,191,207)(H,192,227)(H,193,231)(H,194,234)(H,195,232)(H,196,233)(H,208,209)(H,210,211)(H,212,213)(H,214,215)(H4,160,161,164)/t79-,80-,81-,82-,83+,84+,92-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,121-,122-,123-,124-,125-,126-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 9 | n/a | n/a | n/a | n/a |
The University of Queensland
Curated by ChEMBL
| Assay Description
Agonist activity at human GLP1R expressed in CHOK1 cells assessed as induction of beta-galactosidase-tagged beta-arrestin2 recruitment incubated for ... |
Eur J Med Chem 127: 703-714 (2017)
Article DOI: 10.1016/j.ejmech.2016.10.044
BindingDB Entry DOI: 10.7270/Q2T155W1 |
More data for this
Ligand-Target Pair | |
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