Found 3 hits Enz. Inhib. hit(s) with Target = 'Glucagon-like peptide 1 receptor' and Ligand = 'BDBM50231964' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50231964
(CHEMBL4066546)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCC(=O)NCCCC[C@H](NC(=O)[C@@H](N)Cc2cnc[nH]2)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N1)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(N)=O |r| Show InChI InChI=1S/C155H234N42O46/c1-15-81(10)126(153(242)174-84(13)130(219)184-109(64-89-67-166-94-36-23-22-35-92(89)94)143(232)186-105(60-78(4)5)144(233)194-124(79(6)7)151(240)183-96(37-24-27-55-156)133(222)168-70-117(206)175-95(40-30-58-165-155(161)162)132(221)167-69-115(160)204)196-145(234)107(61-86-31-18-16-19-32-86)188-140(229)103(49-54-122(213)214)182-137(226)97(38-25-28-56-157)178-129(218)83(12)172-128(217)82(11)173-136(225)101(45-50-114(159)203)176-118(207)71-170-135(224)100(48-53-121(211)212)181-141(230)104(59-77(2)3)185-142(231)106(63-88-41-43-91(202)44-42-88)189-148(237)111(73-198)191-150(239)113(75-200)192-152(241)125(80(8)9)195-147(236)110(66-123(215)216)190-149(238)112(74-199)193-154(243)127(85(14)201)197-146(235)108(62-87-33-20-17-21-34-87)187-139(228)102-46-51-116(205)164-57-29-26-39-98(179-131(220)93(158)65-90-68-163-76-171-90)138(227)180-99(47-52-120(209)210)134(223)169-72-119(208)177-102/h16-23,31-36,41-44,67-68,76-85,93,95-113,124-127,166,198-202H,15,24-30,37-40,45-66,69-75,156-158H2,1-14H3,(H2,159,203)(H2,160,204)(H,163,171)(H,164,205)(H,167,221)(H,168,222)(H,169,223)(H,170,224)(H,172,217)(H,173,225)(H,174,242)(H,175,206)(H,176,207)(H,177,208)(H,178,218)(H,179,220)(H,180,227)(H,181,230)(H,182,226)(H,183,240)(H,184,219)(H,185,231)(H,186,232)(H,187,228)(H,188,229)(H,189,237)(H,190,238)(H,191,239)(H,192,241)(H,193,243)(H,194,233)(H,195,236)(H,196,234)(H,197,235)(H,209,210)(H,211,212)(H,213,214)(H,215,216)(H4,161,162,165)/t81-,82-,83-,84-,85+,93-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,124-,125-,126-,127-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| >50 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Queensland
Curated by ChEMBL
| Assay Description
Displacement of [125I]-GLP (7 to 36 residues) from human GLP1R expressed in CHO cell membranes incubated for 30 mins measured after 10 hrs by scintil... |
Eur J Med Chem 127: 703-714 (2017)
Article DOI: 10.1016/j.ejmech.2016.10.044
BindingDB Entry DOI: 10.7270/Q2T155W1 |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50231964
(CHEMBL4066546)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCC(=O)NCCCC[C@H](NC(=O)[C@@H](N)Cc2cnc[nH]2)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N1)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(N)=O |r| Show InChI InChI=1S/C155H234N42O46/c1-15-81(10)126(153(242)174-84(13)130(219)184-109(64-89-67-166-94-36-23-22-35-92(89)94)143(232)186-105(60-78(4)5)144(233)194-124(79(6)7)151(240)183-96(37-24-27-55-156)133(222)168-70-117(206)175-95(40-30-58-165-155(161)162)132(221)167-69-115(160)204)196-145(234)107(61-86-31-18-16-19-32-86)188-140(229)103(49-54-122(213)214)182-137(226)97(38-25-28-56-157)178-129(218)83(12)172-128(217)82(11)173-136(225)101(45-50-114(159)203)176-118(207)71-170-135(224)100(48-53-121(211)212)181-141(230)104(59-77(2)3)185-142(231)106(63-88-41-43-91(202)44-42-88)189-148(237)111(73-198)191-150(239)113(75-200)192-152(241)125(80(8)9)195-147(236)110(66-123(215)216)190-149(238)112(74-199)193-154(243)127(85(14)201)197-146(235)108(62-87-33-20-17-21-34-87)187-139(228)102-46-51-116(205)164-57-29-26-39-98(179-131(220)93(158)65-90-68-163-76-171-90)138(227)180-99(47-52-120(209)210)134(223)169-72-119(208)177-102/h16-23,31-36,41-44,67-68,76-85,93,95-113,124-127,166,198-202H,15,24-30,37-40,45-66,69-75,156-158H2,1-14H3,(H2,159,203)(H2,160,204)(H,163,171)(H,164,205)(H,167,221)(H,168,222)(H,169,223)(H,170,224)(H,172,217)(H,173,225)(H,174,242)(H,175,206)(H,176,207)(H,177,208)(H,178,218)(H,179,220)(H,180,227)(H,181,230)(H,182,226)(H,183,240)(H,184,219)(H,185,231)(H,186,232)(H,187,228)(H,188,229)(H,189,237)(H,190,238)(H,191,239)(H,192,241)(H,193,243)(H,194,233)(H,195,236)(H,196,234)(H,197,235)(H,209,210)(H,211,212)(H,213,214)(H,215,216)(H4,161,162,165)/t81-,82-,83-,84-,85+,93-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,124-,125-,126-,127-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a |
The University of Queensland
Curated by ChEMBL
| Assay Description
Agonist activity at human GLP1R expressed in CHOK1 cells assessed as induction of beta-galactosidase-tagged beta-arrestin2 recruitment incubated for ... |
Eur J Med Chem 127: 703-714 (2017)
Article DOI: 10.1016/j.ejmech.2016.10.044
BindingDB Entry DOI: 10.7270/Q2T155W1 |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50231964
(CHEMBL4066546)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCC(=O)NCCCC[C@H](NC(=O)[C@@H](N)Cc2cnc[nH]2)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N1)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(N)=O |r| Show InChI InChI=1S/C155H234N42O46/c1-15-81(10)126(153(242)174-84(13)130(219)184-109(64-89-67-166-94-36-23-22-35-92(89)94)143(232)186-105(60-78(4)5)144(233)194-124(79(6)7)151(240)183-96(37-24-27-55-156)133(222)168-70-117(206)175-95(40-30-58-165-155(161)162)132(221)167-69-115(160)204)196-145(234)107(61-86-31-18-16-19-32-86)188-140(229)103(49-54-122(213)214)182-137(226)97(38-25-28-56-157)178-129(218)83(12)172-128(217)82(11)173-136(225)101(45-50-114(159)203)176-118(207)71-170-135(224)100(48-53-121(211)212)181-141(230)104(59-77(2)3)185-142(231)106(63-88-41-43-91(202)44-42-88)189-148(237)111(73-198)191-150(239)113(75-200)192-152(241)125(80(8)9)195-147(236)110(66-123(215)216)190-149(238)112(74-199)193-154(243)127(85(14)201)197-146(235)108(62-87-33-20-17-21-34-87)187-139(228)102-46-51-116(205)164-57-29-26-39-98(179-131(220)93(158)65-90-68-163-76-171-90)138(227)180-99(47-52-120(209)210)134(223)169-72-119(208)177-102/h16-23,31-36,41-44,67-68,76-85,93,95-113,124-127,166,198-202H,15,24-30,37-40,45-66,69-75,156-158H2,1-14H3,(H2,159,203)(H2,160,204)(H,163,171)(H,164,205)(H,167,221)(H,168,222)(H,169,223)(H,170,224)(H,172,217)(H,173,225)(H,174,242)(H,175,206)(H,176,207)(H,177,208)(H,178,218)(H,179,220)(H,180,227)(H,181,230)(H,182,226)(H,183,240)(H,184,219)(H,185,231)(H,186,232)(H,187,228)(H,188,229)(H,189,237)(H,190,238)(H,191,239)(H,192,241)(H,193,243)(H,194,233)(H,195,236)(H,196,234)(H,197,235)(H,209,210)(H,211,212)(H,213,214)(H,215,216)(H4,161,162,165)/t81-,82-,83-,84-,85+,93-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,124-,125-,126-,127-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a |
The University of Queensland
Curated by ChEMBL
| Assay Description
Agonist activity at human GLP1R expressed in CHO cells assessed as cAMP accumulation incubated for 30 mins by LANCE assay |
Eur J Med Chem 127: 703-714 (2017)
Article DOI: 10.1016/j.ejmech.2016.10.044
BindingDB Entry DOI: 10.7270/Q2T155W1 |
More data for this
Ligand-Target Pair | |
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