Found 4 hits Enz. Inhib. hit(s) with Target = 'Glucocorticoid receptor' and Ligand = 'BDBM50423192' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50423192
(CHEMBL237973)Show SMILES CCC1(CC(O)(CNC(=O)c2cnn(c2N)-c2ccc(F)cc2)C(F)(F)F)CCCc2ccccc12 Show InChI InChI=1S/C26H28F4N4O2/c1-2-24(13-5-7-17-6-3-4-8-21(17)24)15-25(36,26(28,29)30)16-32-23(35)20-14-33-34(22(20)31)19-11-9-18(27)10-12-19/h3-4,6,8-12,14,36H,2,5,7,13,15-16,31H2,1H3,(H,32,35) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Agonist activity at glucocorticoid receptor in human A549 cells by NF-kappaB transrepression assay |
Bioorg Med Chem Lett 17: 4737-45 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.066 BindingDB Entry DOI: 10.7270/Q2KD206G |
More data for this Ligand-Target Pair | |
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50423192
(CHEMBL237973)Show SMILES CCC1(CC(O)(CNC(=O)c2cnn(c2N)-c2ccc(F)cc2)C(F)(F)F)CCCc2ccccc12 Show InChI InChI=1S/C26H28F4N4O2/c1-2-24(13-5-7-17-6-3-4-8-21(17)24)15-25(36,26(28,29)30)16-32-23(35)20-14-33-34(22(20)31)19-11-9-18(27)10-12-19/h3-4,6,8-12,14,36H,2,5,7,13,15-16,31H2,1H3,(H,32,35) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Agonist activity at glucocorticoid receptor in human A549 cells by NF-kappaB transrepression assay |
Bioorg Med Chem Lett 17: 4737-45 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.066 BindingDB Entry DOI: 10.7270/Q2KD206G |
More data for this Ligand-Target Pair | |
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50423192
(CHEMBL237973)Show SMILES CCC1(CC(O)(CNC(=O)c2cnn(c2N)-c2ccc(F)cc2)C(F)(F)F)CCCc2ccccc12 Show InChI InChI=1S/C26H28F4N4O2/c1-2-24(13-5-7-17-6-3-4-8-21(17)24)15-25(36,26(28,29)30)16-32-23(35)20-14-33-34(22(20)31)19-11-9-18(27)10-12-19/h3-4,6,8-12,14,36H,2,5,7,13,15-16,31H2,1H3,(H,32,35) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 9.80 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Binding affinity to glucocorticoid receptor |
Bioorg Med Chem Lett 17: 4737-45 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.066 BindingDB Entry DOI: 10.7270/Q2KD206G |
More data for this Ligand-Target Pair | |
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50423192
(CHEMBL237973)Show SMILES CCC1(CC(O)(CNC(=O)c2cnn(c2N)-c2ccc(F)cc2)C(F)(F)F)CCCc2ccccc12 Show InChI InChI=1S/C26H28F4N4O2/c1-2-24(13-5-7-17-6-3-4-8-21(17)24)15-25(36,26(28,29)30)16-32-23(35)20-14-33-34(22(20)31)19-11-9-18(27)10-12-19/h3-4,6,8-12,14,36H,2,5,7,13,15-16,31H2,1H3,(H,32,35) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 9.80 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Binding affinity to glucocorticoid receptor |
Bioorg Med Chem Lett 17: 4737-45 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.066 BindingDB Entry DOI: 10.7270/Q2KD206G |
More data for this Ligand-Target Pair | |