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Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Glutaminase kidney isoform, mitochondrial' and Ligand = 'BDBM108919'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))		BDBM108919
PNG
(US8604016, 500 | US9938267, Cmpd ID 500)
Show SMILES O=C(Cc1ccccc1)Nc1nnc(CCCCc2ccc(NC(=O)Cc3cccc(Cn4cccn4)c3)nn2)s1
Show InChI InChI=1S/C30H30N8O2S/c39-27(20-23-10-6-11-24(18-23)21-38-17-7-16-31-38)32-26-15-14-25(34-35-26)12-4-5-13-29-36-37-30(41-29)33-28(40)19-22-8-2-1-3-9-22/h1-3,6-11,14-18H,4-5,12-13,19-21H2,(H,32,35,39)(H,33,37,40)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
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PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 4n/an/an/an/an/an/a



Amgen



Assay Description
Compounds were assessed for their ability to inhibit the enzymatic activity of a recombinant form of Glutaminase 1 (GAC) using a biochemical assay th...

J Med Chem 51: 1681-94 (2008)


BindingDB Entry DOI: 10.7270/Q2JS9SQV
More data for this
Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial


(Homo sapiens (Human))		BDBM108919
PNG
(US8604016, 500 | US9938267, Cmpd ID 500)
Show SMILES O=C(Cc1ccccc1)Nc1nnc(CCCCc2ccc(NC(=O)Cc3cccc(Cn4cccn4)c3)nn2)s1
Show InChI InChI=1S/C30H30N8O2S/c39-27(20-23-10-6-11-24(18-23)21-38-17-7-16-31-38)32-26-15-14-25(34-35-26)12-4-5-13-29-36-37-30(41-29)33-28(40)19-22-8-2-1-3-9-22/h1-3,6-11,14-18H,4-5,12-13,19-21H2,(H,32,35,39)(H,33,37,40)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 4n/an/an/an/an/an/a



Calithera Biosciences Inc.

US Patent


Assay Description
Compounds were assessed for their ability to inhibit the enzymatic activity of a recombinant form of Glutaminase 1 (GAC) using a biochemical assay th...

US Patent US8604016 (2013)


BindingDB Entry DOI: 10.7270/Q2CC0ZBW
More data for this
Ligand-Target Pair