Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human)) | BDBM278400 ((2S)-2-Methoxy-2-phenyl-N-[5-[[(3R)-1-pyridazin-3-...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem | PDB US Patent | n/a | n/a | 15.3 | n/a | n/a | n/a | n/a | 7.8 | n/a |
AstraZeneca AB; Cancer Research Technology Limited US Patent | Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t... | US Patent US10040788 (2018) BindingDB Entry DOI: 10.7270/Q2Z321PG | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human)) | BDBM278400 ((2S)-2-Methoxy-2-phenyl-N-[5-[[(3R)-1-pyridazin-3-...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem | PDB US Patent | n/a | n/a | 16.2 | n/a | n/a | n/a | n/a | 7.8 | n/a |
AstraZeneca AB; Cancer Research Technology Limited US Patent | Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t... | US Patent US10040788 (2018) BindingDB Entry DOI: 10.7270/Q2Z321PG | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human)) | BDBM278400 ((2S)-2-Methoxy-2-phenyl-N-[5-[[(3R)-1-pyridazin-3-...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibition of human KGA (63 to 669 residues) preincubated for 15 mins using 50 mM glutamine as substrate by resorufin dye based assay | J Med Chem 62: 46-59 (2019) Article DOI: 10.1021/acs.jmedchem.8b00327 BindingDB Entry DOI: 10.7270/Q26T0QZ0 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human)) | BDBM278400 ((2S)-2-Methoxy-2-phenyl-N-[5-[[(3R)-1-pyridazin-3-...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca Curated by ChEMBL | Assay Description Inhibition of recombinant 6His-tagged GLS1 KGA isoform (unknown origin) (63 to 669 residues) expressed in Escherichia coli using glutamine as substra... | J Med Chem 62: 6540-6560 (2019) Article DOI: 10.1021/acs.jmedchem.9b00260 BindingDB Entry DOI: 10.7270/Q2QN6B4W | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human)) | BDBM278400 ((2S)-2-Methoxy-2-phenyl-N-[5-[[(3R)-1-pyridazin-3-...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem | PDB US Patent | n/a | n/a | 21.3 | n/a | n/a | n/a | n/a | 7.8 | n/a |
AstraZeneca AB; Cancer Research Technology Limited US Patent | Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t... | US Patent US10040788 (2018) BindingDB Entry DOI: 10.7270/Q2Z321PG | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human)) | BDBM278400 ((2S)-2-Methoxy-2-phenyl-N-[5-[[(3R)-1-pyridazin-3-...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem | PDB US Patent | n/a | n/a | 21.3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company | Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t... | Bioorg Med Chem Lett 18: 1577-82 (2008) BindingDB Entry DOI: 10.7270/Q2MK6G78 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human)) | BDBM278400 ((2S)-2-Methoxy-2-phenyl-N-[5-[[(3R)-1-pyridazin-3-...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | 51 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca Curated by ChEMBL | Assay Description Inhibition of GLS1 GAC isoform (unknown origin) using glutamine as substrate preincubated for 15 mins followed by substrate addition and measured aft... | J Med Chem 62: 6540-6560 (2019) Article DOI: 10.1021/acs.jmedchem.9b00260 BindingDB Entry DOI: 10.7270/Q2QN6B4W | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human)) | BDBM278400 ((2S)-2-Methoxy-2-phenyl-N-[5-[[(3R)-1-pyridazin-3-...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem | PDB US Patent | n/a | n/a | 107 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company | Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t... | Bioorg Med Chem Lett 18: 1577-82 (2008) BindingDB Entry DOI: 10.7270/Q2MK6G78 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human)) | BDBM278400 ((2S)-2-Methoxy-2-phenyl-N-[5-[[(3R)-1-pyridazin-3-...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem | PDB US Patent | n/a | n/a | 119 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company | Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t... | Bioorg Med Chem Lett 18: 1577-82 (2008) BindingDB Entry DOI: 10.7270/Q2MK6G78 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |