new BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Gonadotropin-releasing hormone receptor' and Ligand = 'BDBM50060803'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)
BDBM50060803
PNG
(CHEMBL436897 | [L or DAgl (isonicotinoyl)3]acyline)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](Cc1ccc(NC(C)=O)cc1)NC(=O)[C@H](Cc1ccc(NC(C)=O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(C)=O)NC(=O)c1ccncc1)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@@H]1C(=O)N[C@H](C)C(N)=O
Show InChI InChI=1S/C80H101ClN16O15/c1-45(2)38-62(72(104)89-61(16-11-12-34-84-46(3)4)80(112)97-37-13-17-68(97)78(110)85-47(5)69(82)102)90-74(106)64(41-52-21-28-59(29-22-52)86-48(6)99)91-75(107)65(42-53-23-30-60(31-24-53)87-49(7)100)93-77(109)67(44-98)94-79(111)70(95-71(103)56-32-35-83-36-33-56)96-76(108)66(40-51-19-26-58(81)27-20-51)92-73(105)63(88-50(8)101)43-54-18-25-55-14-9-10-15-57(55)39-54/h9-10,14-15,18-33,35-36,39,45-47,61-68,70,84,98H,11-13,16-17,34,37-38,40-44H2,1-8H3,(H2,82,102)(H,85,110)(H,86,99)(H,87,100)(H,88,101)(H,89,104)(H,90,106)(H,91,107)(H,92,105)(H,93,109)(H,94,111)(H,95,103)(H,96,108)/t47-,61+,62+,63-,64-,65+,66-,67+,68-,70+/m1/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.40n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Inhibition of binding of radiolabeled histrelin to Gonadotropin-releasing hormone receptor (GnRHr) in rat pituitary gland membranes


J Med Chem 40: 3739-48 (1997)


Article DOI: 10.1021/jm970024p
BindingDB Entry DOI: 10.7270/Q24J0D8X
More data for this
Ligand-Target Pair