new BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Gonadotropin-releasing hormone receptor' and Ligand = 'BDBM50060804'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)
BDBM50060804
PNG
(CHEMBL269097 | [D/LAgl (isobutyryl)7]acyline)
Show SMILES CC(C)CC(=O)N[C@H](NC(=O)[C@@H](Cc1ccc(NC(C)=O)cc1)NC(=O)[C@H](Cc1ccc(NC(C)=O)cc1)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc1cccnc1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(C)=O)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@@H]1C(=O)N[C@H](C)C(N)=O
Show InChI InChI=1S/C81H103ClN16O15/c1-46(2)37-70(103)96-72(80(112)90-62(18-11-12-35-85-47(3)4)81(113)98-36-14-19-69(98)79(111)86-48(5)71(83)104)97-77(109)66(41-54-25-32-61(33-26-54)88-50(7)101)92-75(107)65(40-53-23-30-60(31-24-53)87-49(6)100)94-78(110)68(45-99)95-76(108)67(43-56-15-13-34-84-44-56)93-74(106)64(39-52-21-28-59(82)29-22-52)91-73(105)63(89-51(8)102)42-55-20-27-57-16-9-10-17-58(57)38-55/h9-10,13,15-17,20-34,38,44,46-48,62-69,72,85,99H,11-12,14,18-19,35-37,39-43,45H2,1-8H3,(H2,83,104)(H,86,111)(H,87,100)(H,88,101)(H,89,102)(H,90,112)(H,91,105)(H,92,107)(H,93,106)(H,94,110)(H,95,108)(H,96,103)(H,97,109)/t48-,62+,63-,64-,65+,66-,67-,68+,69-,72-/m1/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 2n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Inhibition of binding of radiolabeled histrelin to Gonadotropin-releasing hormone receptor (GnRHr) in rat pituitary gland membranes


J Med Chem 40: 3739-48 (1997)


Article DOI: 10.1021/jm970024p
BindingDB Entry DOI: 10.7270/Q24J0D8X
More data for this
Ligand-Target Pair